Activation of rat mast cells upon stimulation of protease-activated receptor (PAR-1)

被引：12
|
作者：
Umarova, BA
Dugina, TN
Shestakova, EV
Gluza, E
Strukova, SM
机构：
[1] Moscow MV Lomonosov State Univ, Dept Human & Anim Physiol, Moscow 117234, Russia
[2] Univ Jena, Ctr Vasc Surg & Med, Erfurt, Germany
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2000年 / 129卷 / 04期
关键词：
mast cells; proteolytically cleaved receptor; thrombin; beta-hexosaminidase; heparin;
D O I：
10.1007/BF02439253
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In vivo experiments on the model of wound healing showed that thrombin and thrombin receptor agonist TRAP-6 stimulated heparin secretion by mast cells in rat subcutaneous fat: the saturation of mast cells with heparin decreased, while degranulation and granulolysis increased. In vitro studies showed that TRAP-6 caused a dose-dependent release of beta-hexosaminidase from peritoneal mast cells. TRAP-6 also induced heparin release from these cells and inhibition of amidase activity of thrombin. Heparin released from mast cells had low anticoagulant activity. These data suggest that activation of mast cells with thrombin is mediated by PAR-1.
引用
收藏
页码：314 / 317
页数：4
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