HLA class I and class II matched donor material for improved corneal allograft survival

被引：0
|
作者：
Volker-Dieben, HJ [1 ]
D'Amaro, J [1 ]
机构：
[1] Free Univ Amsterdam Hosp, Dept Ophthalmol, Amsterdam, Netherlands
来源：
IMMUNOGENETICS: ADVANCES AND EDUCATION: THE FIRST CONGRESS OF THE SLOVAK FOUNDATION | 1997年 / 35卷
关键词：
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Corneal graft survival was assessed within a large prospectively collected database of 2103 consecutive corneal grafts in a single center. HLA Class I antigen matching significantly improved graft survival in no only high risk recipients (p < 0.001) but also in low risk recipients (p = 0.0001). This effect was also present in a subset of 606 Organ cultured donor corneas for high risk patients (p = 0.05). Graft failures were observed in 608 transplants, 45.5% were due to immunological rejection. The beneficial effect of HLA Class II antigen matching on graft survival in 233 high risk patients (p = 0.02) and in a subset of 99 herpes keratitis patients (p = 0.05) was found after exclusion of the patients with non-immunological graft failures.
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页码：203 / 214
页数：12
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