In vivo modulation of HMGA2 expression

被引：46
|
作者：
Ashar, Hena R. [2 ]
Chouinard, Roland A., Jr. [2 ]
Dokur, Madhavi [2 ]
Chada, Kiran [1 ,2 ]
机构：
[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Biochem, Piscataway, NJ 08854 USA
[2] HMGene Inc, New Brunswick, NJ 08902 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2010年 / 1799卷 / 1-2期
关键词：
HMGA2; Mesenchymal proliferation; Adipogenesis; Spermatogenesis; TRANSGENIC INSERTIONAL MUTANT; BENIGN MESENCHYMAL TUMORS; GROUP PROTEIN GENE; TRANSLOCATION BREAKPOINTS; UTERINE LEIOMYOMATA; CELL-PROLIFERATION; SELF-RENEWAL; HMGIC GENE; MINI-MOUSE; STEM-CELLS;
D O I：
10.1016/j.bbagrm.2009.11.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
While the biochemical role of the HMGA proteins has largely been elucidated in tissue culture, the majority of the insight as to their physiological functions in the processes of proliferation and development has been established in animal models of overexpression (transgenic) and null mice (knockouts). An emphasis has been placed on the HMGA2 studies which have defined its critical role in mesenchymal proliferation and differentiation. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：55 / 61
页数：7
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