DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in leukemic cells.

被引：0
|
作者：
Halicka, DH
Huang, X
Ozkaynak, FM
Seiter, K
Traganos, F
Darzynkiewicz, Z
机构：
[1] New York Med Coll, Brander Canc Res Inst, Hawthorne, NY USA
[2] Westchester Med Ctr, Div Hematol Oncol, Valhalla, NY USA
来源：
BLOOD | 2004年 / 104卷 / 11期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
4240
引用
收藏
页码：146B / 146B
页数：1
相关论文
共 50 条
  • [1] DNA Damage Induced by DNA Topoisomerase I- and Topoisomerase II-Inhibitors Detected by Histone H2AXphosphorylation in Relation to the Cell Cycle Phase and Apoptosis
    Huang, Xuan
    Traganos, Frank
    Darzynkiewicz, Zbigniew
    CELL CYCLE, 2003, 2 (06) : 614 - 619
  • [2] Phosphorylated histone H2Ax in PBMCs as a pharmacodynamic surrogate response to DNA damage by topoisomerase I inhibitors
    Ji, Jay
    Yutzy, Will
    Putvatana, Ravithat
    Zhang, Yiping
    Kinders, Robert J.
    Parchment, Ralph E.
    Hollingshead, Melinda G.
    Tomaszewski, Joseph E.
    Doroshow, James H.
    MOLECULAR CANCER THERAPEUTICS, 2007, 6 (12) : 3542S - 3542S
  • [3] Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin
    Huang, X
    Okafuji, M
    Traganos, F
    Luther, E
    Holden, E
    Darzynkiewicz, Z
    CYTOMETRY PART A, 2004, 58A (02) : 99 - 110
  • [4] ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis
    Tanaka, T
    Kurose, A
    Huang, X
    Dai, W
    Darzynkiewicz, Z
    CELL PROLIFERATION, 2006, 39 (01) : 49 - 60
  • [5] Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis
    Kurose, A
    Tanaka, T
    Huang, X
    Halicka, HD
    Traganos, F
    Dai', W
    Darzynkiewicz, Z
    CYTOMETRY PART A, 2005, 68A (01) : 1 - 9
  • [6] Detection of DNA damage in individual cells by analysis of histone H2AX phosphorylation
    Olive, PL
    CYTOMETRY, 4TH EDITION: NEW DEVELOPMENTS, 2004, 75 : 355 - 373
  • [7] Phosphorylation of BLM, dissociation from topoisomerase IIIα, and colocalization with γ-H2AX after topoisomerase I-Induced replication damage
    Rao, VA
    Fan, AM
    Meng, LH
    Doe, CF
    North, PS
    Hickson, ID
    Pommier, Y
    MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (20) : 8925 - 8937
  • [8] Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage Response
    Wu, Ching-Yuan
    Kang, Hong-Yo
    Yang, Wei-Lei
    Wu, Juan
    Jeong, Yun Seong
    Wang, Jing
    Chan, Chia-Hsin
    Lee, Szu-Wei
    Zhang, Xian
    Lamothe, Betty
    Campos, Alejandro D.
    Darnay, Bryant G.
    Lin, Hui-Kuan
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (35) : 30806 - 30815
  • [9] Factors that Induce DNA Damage Involving Histone H2AX Phosphorylation
    Fernandes-Ferreira, Rafael
    Silva Souza, Doroteia Rossi
    Souza, Antonio Soares
    RADIOLOGY, 2015, 277 (01) : 307 - 308
  • [10] Synchronization in the cell cycle by inhibitors of DNA replication induces histone H2AX phosphorylation: an indication of DNA damage
    Kurose, A
    Tanaka, T
    Huang, X
    Traganos, F
    Darzynkiewicz, Z
    CELL PROLIFERATION, 2006, 39 (03) : 231 - 240
12345