Anti-inflammatory Action of Toothpastes Containing Betulin Nanocapsules

Nanomedicine may be defined as an application of nanotechnologyin the field of health, healthcare, diagnosis and treatment of diseases, with the purpose of maintaining and/or improving populational health. This is also applicable to dental medicine. The aim of this study was to design a toothpaste based on natural ingredients, with antiinflammatory and antibacterial proprieties which could be used to decrease the degree of gingival inflammation. In order to increase the biodisponibility of the therapeutic substance i.e. birch sap extract, it has been incorporated into polyester urethane nanocapsules thus being more easily transported to its action site. After the invention patent was published for the composition of this toothpaste, it was tested on 32 volunteers. After using the toothpaste for two weeks, the gingival inflammation index (GI) decreased from an average of 2.3 to 1.028.