Synthesis of 3-substituted indole derivatives

The research of indoles has been one of the most active areas of heterocyclic chemistry. In particular, 3-substituted indole derivatives have received much attention as building blocks for the synthesis of many natural products and other biologically active compounds. Recently, there are a lot of reports on the synthesis of 3-substitutued indoles from indole. In this article, The one-pot synthesis of 3-substituted indole derivatives from indoles, such as bis(indolyl) methane, beta-indolylketone, beta-indolylalcohol, beta-indolylnitro-compound, alpha-indolylmethylamine is reviewed according to the kinds of catalysts.