CImbinator: a web-based tool for drug synergy analysis in small- and large-scale datasets

被引：11
|
作者：
Flobak, Asmund [1 ]
Vazquez, Miguel [1 ,2 ]
Laegreid, Astrid [1 ]
Valencia, Alfonso [2 ,3 ,4 ]
机构：
[1] Norwegian Univ Sci & Technol NTNU, Dept Canc Res & Mol Med, N-7491 Trondheim, Norway
[2] CNIO Spanish Natl Canc Res Ctr, Struct Biol & Biocomp Programme, Struct Computat Biol Grp, Madrid, Spain
[3] Barcelona Supercomp Ctr, Life Sci Dept, Joint BSC CRG IRB Program Computat Biol, Barcelona, Spain
[4] ICREA, Barcelona, Spain
来源：
BIOINFORMATICS | 2017年 / 33卷 / 15期
关键词：
COMBINATIONS; RESISTANCE; CANCER;
D O I：
10.1093/bioinformatics/btx161
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Motivation: Drug synergies are sought to identify combinations of drugs particularly beneficial. User-friendly software solutions that can assist analysis of large-scale datasets are required. Results: CImbinator is a web-service that can aid in batch-wise and in-depth analyzes of data from small-scale and large-scale drug combination screens. CImbinator offers to quantify drug combination effects, using both the commonly employed median effect equation, as well as advanced experimental mathematical models describing dose response relationships.
引用
收藏
页码：2410 / 2412
页数：3
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