Non-adiabatic membrane voltage fluctuations driven by two ligand-gated ion channels

被引:2
|
作者
Fan, Yan-Hua [1 ]
Wang, Jia-Zeng [1 ]
机构
[1] Beijing Technol & Business Univ, Dept Math, Beijing 100048, Peoples R China
基金
中国国家自然科学基金;
关键词
ACETYLCHOLINE-RECEPTOR; MOLECULAR DISSECTION; SUBUNIT INTERFACES; IDENTIFICATION;
D O I
10.1063/1.5096303
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
In this paper, we construct a piecewise deterministic Markov process to model the membrane voltage fluctuations driven by two ligand-gated channels. The series-solution method is applied to the third-order ordinary differential equations to get its general solutions. Also, the stationary probability density function (PDF) is just the special solution that satisfies certain boundary conditions. The bifurcation conditions of the PDF at the boundary are obtained analytically. As an application, the PDF is used to calculate the power dissipation of the ionic currents in the (nonequilibrium) steady states.
引用
收藏
页数:12
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