Bronchial asthma: Risk factors and ways to prevent early unfavorable outcomes

Aim. Study of late outcomes of bronchial asthma (BA) and factors of risk of rapidly progressive BA course. Materials and Methods. A 10-year retrospective trial. Examination of 118 patients with BA aged 17-74 years. Results. A rapid progression of BA observed in 17(14%) patients led to an unfavorable outcome (death, life-threatening conditions, invalidism) as early as the first year of the observation. Relevant factors of risk were active eosinophil endobronchitis found at fibrobronchoscopy, concomitant active nonspecific infection in the bronchi, unjustified use of oral corticosteroids when inhalation steroids were possible, family problems. Conclusion. Active secondary prophylaxis is necessary in patients at high risk of rapidly progressive BA.