A 47-year-old man with a history of hypertension presented to an urgent care ambulatory clinic with a 3-day history of swelling around his left eye and a sensation of tightness in his throat. He reported no pruritus, photophobia, diplopia, headache, changes in visual acuity, or pain. He was hoarse but did not have wheezing or shortness of breath. During the 3 days before presentation, it had become difficult for him to swallow solids, and he felt as if food was sticking in his throat. He reported no fevers, fatigue, gastrointestinal symptoms, or recent illness. Copyright © 2016 Massachusetts Medical Society. All rights reserved.