Responses of Human Medial Temporal Lobe Neurons Are Modulated by Stimulus Repetition

被引：34

作者：

Pedreira, Carlos ^{[1
]}

Mormann, Florian ^{[2
,3
,4
]}

Kraskov, Alexander ^{[2
,5
]}

Cerf, Moran ^{[2
,3
,4
]}

Fried, Itzhak ^{[3
,4
,6
,7
]}

Koch, Christof ^{[2
]}

Quiroga, Rodrigo Quian ^{[1
,2
,3
,4
]}

机构：

[1] Univ Leicester, Dept Engn, Leicester LE1 7RH, Leics, England

[2] CALTECH, Pasadena, CA 91125 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA USA

[5] UCL, Inst Neurol, London, England

[6] Tel Aviv Med Ctr & Sch Med, Funct Neurosurg Unit, Tel Aviv, Israel

[7] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

来源：

JOURNAL OF NEUROPHYSIOLOGY | 2010年 / 103卷 / 01期

基金：

英国工程与自然科学研究理事会; 英国医学研究理事会;

关键词：

LONG-TERM-MEMORY; SINGLE NEURONS; RECOGNITION MEMORY; HUMAN HIPPOCAMPUS; HUMAN BRAIN; INFEROTEMPORAL CORTEX; VISUAL RECOGNITION; PERIRHINAL CORTEX; NEURAL MECHANISMS; AMYGDALA;

D O I：

10.1152/jn.91323.2008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pedreira C, Mormann F, Kraskov A, Cerf M, Fried I, Koch C, Quiroga RQ. Responses of human medial temporal lobe neurons are modulated by stimulus repetition. J Neurophysiol 103: 97-107, 2010. First published October 28, 2009; doi:10.1152/jn.91323.2008. Recent studies have reported the presence of single neurons with strong responses to visual inputs in the human medial temporal lobe. Here we show how repeated stimulus presentation-photos of celebrities and familiar individuals, landmark buildings, animals, and objects-modulates the firing rate of these cells: a consistent decrease in the neural activity was registered as images were repeatedly shown during experimental sessions. The effect of repeated stimulus presentation was not the same for all medial temporal lobe areas. These findings are consistent with the view that medial temporal lobe neurons link visual percepts to declarative memory.

引用

页码：97 / 107

页数：11

共 50 条

[1] Learning of anticipatory responses in single neurons of the human medial temporal lobe
Reddy, Leila
Poncet, Marlene
Self, Matthew W.
Peters, Judith C.
Douw, Linda
van Dellen, Edwin
Claus, Steven
Reijneveld, Jaap C.
Baayen, Johannes C.
Roelfsema, Pieter R.
[J]. NATURE COMMUNICATIONS, 2015, 6
[2] Learning of anticipatory responses in single neurons of the human medial temporal lobe
Leila Reddy
Marlene Poncet
Matthew W. Self
Judith C. Peters
Linda Douw
Edwin van Dellen
Steven Claus
Jaap C. Reijneveld
Johannes C. Baayen
Pieter R. Roelfsema
[J]. Nature Communications, 6
[3] Grandmother neurons in the human medial temporal lobe
Koch, Christof
[J]. NEUROSCIENCE RESEARCH, 2010, 68 : E24 - E24
[4] Category-specific visual responses of single neurons in the human medial temporal lobe
Kreiman, G
Koch, C
Fried, I
[J]. NATURE NEUROSCIENCE, 2000, 3 (09) : 946 - 953
[5] Category-specific visual responses of single neurons in the human medial temporal lobe
Gabriel Kreiman
Christof Koch
Itzhak Fried
[J]. Nature Neuroscience, 2000, 3 : 946 - 953
[6] Stimulus-specific novelty encoding and subsequent memory responses in human medial temporal lobe
Preston, AR
Gaare, ME
Wagner, AD
[J]. JOURNAL OF COGNITIVE NEUROSCIENCE, 2005, : 134 - 135
[7] Neural Repetition Effects in the Medial Temporal Lobe Complex are Modulated by Previous Encoding Experience
Greene, Ciara M.
Soto, David
[J]. PLOS ONE, 2012, 7 (07):
[8] Responses of single neurons in the human medial temporal lobe during visual stimulation, imagery, and flash suppression
Koch, C
[J]. PERCEPTION, 2002, 31 : 104 - 104
[9] Inhibitory and excitatory responses of single neurons in the human medial temporal lobe during recognition of faces and objects
Fried, I
Cameron, KA
Yashar, S
Fong, R
Morrow, JW
[J]. CEREBRAL CORTEX, 2002, 12 (06) : 575 - 584
[10] Representation of retrieval confidence by single neurons in the human medial temporal lobe
Rutishauser, Ueli
Ye, Shengxuan
Koroma, Matthieu
Tudusciuc, Oana
Ross, Ian B.
Chung, Jeffrey M.
Mamelak, Adam N.
[J]. NATURE NEUROSCIENCE, 2015, 18 (07) : 1041 - +

← 1 2 3 4 5 →