Myritonines A-C, Alkaloids from Myrioneuron tonkinensis Based on a Novel Hexacyclic Skeleton

被引：15
|
作者：
Li, Xiao-Hui [1 ,2 ]
Zhang, Yu [1 ]
Zhang, Jia-Hui [1 ]
Li, Xiao-Nian [1 ]
Cao, Ming-Ming [1 ]
Di, Ying-Tong [1 ]
Peng, Zong-Gen [3 ,4 ]
Jiang, Jian-Dong [3 ,4 ]
Hao, Xiao-Jiang [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West, Kunming 650201, Yunnan, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
[3] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
[4] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 04期
基金：
中国国家自然科学基金;
关键词：
FABERI; NUTANS;
D O I：
10.1021/acs.jnatprod.5b01130
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Myritonines A-C (1-3), three new alkaloids bearing an unprecedented heterohexacyclic skeleton, were isolated from Myrioneuron tonkinensis. Their structures were determined by a combination of spectroscopic data and single crystal X-ray diffraction analysis. Compound 3 represents the first Myrioneuron alkaloid featuring a unique trans-decahydroquinoline motif and was also found to possess a rare cyano functionality. Compounds 1 and 2 showed inhibition against the hepatitis C virus in vitro.
引用
收藏
页码：1203 / 1207
页数：5
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