Globular carbohydrate macromolecule "sugar balls", 2 -: Synthesis of mono(glycopeptide)-persubstituted dendrimers by polymer reaction with sugar-substituted α-amino acid N-carboxyanhydrides (glycoNCAs)

被引：0

作者：

Aoi, K ^{[1
]}

Tsutsumiuchi, K ^{[1
]}

Yamamoto, A ^{[1
]}

Okada, M ^{[1
]}

机构：

[1] Nagoya Univ, Fac Agr Sci, Dept Appl Biol Sci, Chikusa Ku, Nagoya, Aichi 46401, Japan

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 1998年 / 19卷 / 01期

关键词：

D O I：

10.1002/(SICI)1521-3927(19980101)19:1<5::AID-MARC5>3.0.CO;2-R

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Sugar-substituted alpha-amino acid N-carboxyanhydrides (glycoNCAs), i.e., O-(tetra-O-acetyl-beta-D-glucopyranosyl)-L-serine NCA (2a) and O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-beta-D-glucopyranosyl)-L-serine NCA (2b), were successfully used for the introduction of a mono(glycopeptide) unit into each terminal primary amino group of a dendrimer. Well-defined dendrimer-based artificial glycoconjugates, O-(beta-D-glucopyranosyl)-L-serine-persubstituted poly(amido amine) (PAMAM) dendrimer (3a) and O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-serine-persubstituted PAMAM dendrimer (3b), were synthesized by polymer reaction of PAMAM dendrimer with 2a and 2b, respectively, followed by deacetylation with hydrazine monohydrate.

引用

页码：5 / 9

页数：5

共 6 条

[1] Globular carbohydrate macromolecule ''sugar balls'' .3. ''Radial-growth polymerization'' of sugar-substituted alpha-amino acid N-carboxyanhydrides (GlycoNCAs) with a dendritic initiator
Aoi, K
Tsutsumiuchi, K
Yamamoto, A
Okada, M
TETRAHEDRON, 1997, 53 (45) : 15415 - 15427
[2] Synthesis of glycopeptide-conjugates via ring-opening polymerization of sugar-substituted α-amino acid N-carboxyanhydrides (GlycoNCAs)
Okada, M
Aoi, K
Tsutsumiuchi, K
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1997, 73 (10): : 205 - 209
[3] GLOBULAR CARBOHYDRATE MACROMOLECULE SUGAR BALLS .1. SYNTHESIS OF NOVEL SUGAR-PERSUBSTITUTED POLY(AMIDO AMINE) DENDRIMERS
AOI, K
ITOH, K
OKADA, M
MACROMOLECULES, 1995, 28 (15) : 5391 - 5393
[4] Synthesis of polyoxazoline-(glyco)peptide block copolymers by ring-opening polymerization of (sugar-substituted) alpha-amino acid N-carboxyanhydrides with polyoxazoline macroinitiators
Tsutsumiuchi, K
Aoi, K
Okada, M
MACROMOLECULES, 1997, 30 (14) : 4013 - 4017
[5] GLYCOPEPTIDE SYNTHESIS BY AN ALPHA-AMINO-ACID N-CARBOXYANHYDRIDE (NCA) METHOD - RING-OPENING POLYMERIZATION OF A SUGAR-SUBSTITUTED NCA
AOI, K
TSUTSUMIUCHI, K
OKADA, M
MACROMOLECULES, 1994, 27 (03) : 875 - 877
[6] Acylation of sugar hydroxyl groups with N-boc amino acid N-carboxyanhydrides (BOC-NCAS). Synthesis of amino acid saccharide conjugates.
Cabaret, D
Wakselman, M
Kaba, A
Ilunga, L
Chany, C
SYNTHETIC COMMUNICATIONS, 1998, 28 (14) : 2713 - 2724

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