Autoimmune Hepatitis in a Patient With Common Variable Immunodeficiency

被引：4

作者：

Myneedu, Kanchana ^{[1
]}

Chavez, Luis O. ^{[1
]}

Sussman, Norman L. ^{[2
]}

Michael, Majd ^{[3
]}

Padilla, Angelica ^{[4
]}

Zuckerman, Marc J. ^{[3
]}

机构：

[1] Texas Tech Univ, Dept Internal Med, Hlth Sci Ctr, El Paso, TX USA

[2] Baylor Coll Med, Abdominal Transplant & Liver Dis Clin, Houston, TX 77030 USA

[3] Texas Tech Univ, Div Gastroenterol, Hlth Sci Ctr, El Paso, TX 79901 USA

[4] Texas Tech Univ, Dept Pathol, Hlth Sci Ctr, El Paso, TX USA

来源：

ACG CASE REPORTS JOURNAL | 2021年 / 8卷 / 03期

关键词：

LIVER-TRANSPLANTATION; DISEASE;

D O I：

10.14309/crj.0000000000000547

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Common variable immunodeficiency (CVID) is characterized by defective immunoglobulin synthesis because of impaired B-cell function. Liver abnormalities including autoimmune hepatitis (AIH) have been described in up to 10% of patients. We report a 27-year-old woman with CVID who presented with liver dysfunction secondary to AIH. AIH is both uncommon and challenging diagnostically in patients with CVID because they have low IgG levels and often have low or undetectable autoantibody levels. Liver biopsy and response to therapy play an important role in establishing the diagnosis. Corticosteroids are the mainstay of therapy, with or without immune modulators.

引用

页数：3

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