Helicobacter pylori CagA -: a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteins

被引：66
|
作者：
Hatakeyama, M
机构：
[1] Hokkaido Univ, Div Mol Oncol, Inst Med Genet, Kita Ku, Sapporo, Hokkaido 0600815, Japan
[2] Hokkaido Univ, Div Chem, Grad Sch Sci, Kita Ku, Sapporo, Hokkaido 0600815, Japan
来源：
MICROBES AND INFECTION | 2003年 / 5卷 / 02期
关键词：
Helicobacter pylori; CagA; SHP-2; Gab; gastric carcinoma;
D O I：
10.1016/S1286-4579(02)00085-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Helicobacter pylori virulence factor CagA is injected into gastric epithelial cells and undergoes tyrosine phosphorylation. Similar to mammalian Gab protein, tyrosine-phosphorylated CagA recruits and activates SHP-2 phosphatase at the plasma membrane, thereby inducing a growth factor-like effect. CagA-SHP-2 interaction may play an important role in bacterial pathogenesis, leading to gastric carcinoma. (C) 2003 Editions scientitiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：143 / 150
页数：8
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