One step synthesis of orthogonally protected diaminodicarboxylic acids by mixed Kolbe electrolysis

被引：11
|
作者：
Hiebl, J
Kollmann, H
Rovenszky, F
Winkler, K
机构：
[1] Topcro Pharma Res GmbH, A-4020 Linz, Austria
[2] Hafslund Nycombed Pharma AG, A-4020 Linz, Austria
[3] Nycomed Austria GmbH, A-4020 Linz, Austria
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 23期
关键词：
D O I：
10.1016/S0960-894X(97)10130-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Orthogonally protected 2,5-diaminoadipic, 2,6-diaminopimelic, and 2,7-diaminosuberic acid derivatives bearing up to four different protecting groups are prepared in one step by mixed Kolbe electrolysis. The use of 2-[(4-methylphenyl)sulfonyl]ethyl group is crucial for the isolation of the desired orthogonally protected products. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：2963 / 2966
页数：4
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