Oncolytic Bacteria and their potential role in bacterium-mediated tumour therapy: a conceptual analysis

被引：23

作者：

Wang, Yuqing ^{[1
]}

Guo, Wenxuan ^{[1
]}

Wu, XiaoLi ^{[2
]}

Zhang, Ying ^{[3
]}

Mannion, Ciaran ^{[4
]}

Brouchkov, Anatoli ^{[5
,6
]}

Man, Yan-Gao ^{[7
]}

Chen, Tingtao ^{[1
]}

机构：

[1] Nanchang Univ, Inst Translat Med, Nanchang 330031, Jiangxi, Peoples R China

[2] JiangXi Univ Tradit Chinese Med, Coll Basic Med, Nanchang 330000, Jiangxi, Peoples R China

[3] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA

[4] Hackensack Univ, Med Ctr, Hackensack, NJ USA

[5] Lomonosov Moscow State Univ, Leninskie Gory, Moscow 119991, Russia

[6] Tyumen State Univ, Volodarskogo 6, Tyumen 625003, Russia

[7] Hackensack Univ, Med Ctr, Hackensack Meridian Hlth, Dept Pathol, Hackensack, NJ 07601 USA

来源：

JOURNAL OF CANCER | 2019年 / 10卷 / 19期

基金：

中国国家自然科学基金;

关键词：

Engineered bacteria; Tumour therapy; Human microbiota; Probiotics; RECOMBINANT LISTERIA-MONOCYTOGENES; CYTOSINE DEAMINASE GENE; LACTIC-ACID BACTERIA; BACILLUS-THURINGIENSIS; SALMONELLA-TYPHIMURIUM; BIFIDOBACTERIUM-LONGUM; SELECTIVE LOCALIZATION; PARASPORAL INCLUSIONS; ENGINEERING BACTERIA; ESTABLISHED TUMORS;

D O I：

10.7150/jca.35648

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As the human microbiota has been confirmed to be of great significance in maintaining health, the dominant bacteria in them have been applied as probiotics to treat various diseases. After the detection of bacteria in tumours, which had previously been considered a sterile region, these bacteria have been isolated and genetically modified for use in tumour therapy. In this review, we sum up the main types of bacteria used in tumour therapy and reveal the mechanisms of both wild type and engineered bacteria in eliminating tumour cells, providing potential possibilities for newly detected, genetically modified, tumour-associated bacteria in anti-tumour therapy.

引用

页码：4442 / 4454

页数：13

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