Felbamate overdose complicated by massive crystalluria and acute renal failure

被引：6
|
作者：
Rengstorff, DS [1 ]
Milstone, AP [1 ]
Seger, DL [1 ]
Meredith, TJ [1 ]
机构：
[1] Vanderbilt Univ, Med Ctr, Div Allergy Pulm & Crit Care Med, Nashville, TN 37232 USA
来源：
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY | 2000年 / 38卷 / 06期
关键词：
D O I：
10.1081/CLT-100102019
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Case Report: We report a 20-year-old woman who developed altered mental status, massive crystalluria, and acute renal failure following an intentional overdose of felbamate and sodium valproate, Peak plasma concentrations of felbamate and sodium valproate were 200 mug/mL and 370 mug/mL, respectively. Macroscopic urinary crystals formed approximately 18 hours after ingestion and mere identified bg gas chromatography as containing felbamate, Renal ultrasound revealed unilateral hydronephrosis. Following parenteral hydration, the crystalluria and acute renal failure resolved and the patient recovered. The frequency and significance of crystalluria in felbamate intoxication is unknown.
引用
收藏
页码：667 / 669
页数：3
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