Selective rapid B-cell depletion in vivo by pharmacologic IKK2 inhibition.

被引:0
|
作者
Fraser, CC [1 ]
Nagashima, K [1 ]
Sasseville, V [1 ]
Deeds, J [1 ]
McDonald, A [1 ]
Simpson, C [1 ]
Xu, YJ [1 ]
机构
[1] Millennium Pharmaceut, Inflammat, Cambridge, MA USA
关键词
D O I
10.1182/blood.V104.11.2481.2481
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
2481
引用
下载
收藏
页码:680A / 681A
页数:2
相关论文
共 50 条
  • [1] A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation
    Stefanie Voigt
    Kai R. Sterz
    Fabian Giehler
    Anne-Wiebe Mohr
    Joanna B. Wilson
    Andreas Moosmann
    Arnd Kieser
    Nature Communications, 11
  • [2] A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation
    Voigt, Stefanie
    Sterz, Kai R.
    Giehler, Fabian
    Mohr, Anne-Wiebe
    Wilson, Joanna B.
    Moosmann, Andreas
    Kieser, Arnd
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [3] Characterization of retinal cell inflammatory cytokine amplification and IKK2 inhibition
    Morales, Monica
    Jhala, Marvarakumari
    Palmer, Sam A.
    Penn, John S.
    Padovani-Claudio, Dolly Ann
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2023, 64 (08)
  • [4] Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model
    Xia, Yifeng
    Yeddula, Narayana
    Leblanc, Mathias
    Ke, Eugene
    Zhang, Yonghui
    Oldfield, Eric
    Shaw, Reuben J.
    Verma, Inder M.
    NATURE CELL BIOLOGY, 2012, 14 (03) : 257 - +
  • [5] Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model
    Yifeng Xia
    Narayana Yeddula
    Mathias Leblanc
    Eugene Ke
    Yonghui Zhang
    Eric Oldfield
    Reuben J. Shaw
    Inder M. Verma
    Nature Cell Biology, 2012, 14 : 257 - 265
  • [6] Targeting NF-κB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth
    Jourdan, Michel
    Moreaux, Jerome
    De Vos, John
    Hose, Dirk
    Mahtouk, Karene
    Abouladze, Matthieu
    Robert, Nicolas
    Baudard, Marion
    Reme, Thierry
    Romanelli, Angela
    Goldschmidt, Hartmut
    Rossi, Jean-Francois
    Dreano, Michel
    Klein, Bernard
    BRITISH JOURNAL OF HAEMATOLOGY, 2007, 138 (02) : 160 - 168
  • [7] Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKβ
    Nagashima, Kumiko
    Sasseville, Vito G.
    Wen, Danyi
    Bielecki, Andrew
    Yang, Hua
    Simpson, Chris
    Grant, Ethan
    Hepperle, Michael
    Harriman, Gerry
    Jaffee, Bruce
    Ocain, Tim
    Xu, Yajun
    Fraser, Christopher C.
    BLOOD, 2006, 107 (11) : 4266 - 4273
  • [8] Correction: Corrigendum: Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model
    Yifeng Xia
    Narayana Yeddula
    Mathias Leblanc
    Eugene Ke
    Yonghui Zhang
    Eric Oldfield
    Reuben J. Shaw
    Inder M. Verma
    Nature Cell Biology, 2015, 17 (4) : 532 - 532
  • [9] Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration
    Lattke, Michael
    Reichel, Stephanie N.
    Magnutzki, Alexander
    Abaei, Alireza
    Rasche, Volker
    Walther, Paul
    Calado, Dinis P.
    Ferger, Boris
    Wirth, Thomas
    Baumann, Bernd
    MOLECULAR NEURODEGENERATION, 2017, 12 : 1 - 20
  • [10] Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration
    Michael Lattke
    Stephanie N. Reichel
    Alexander Magnutzki
    Alireza Abaei
    Volker Rasche
    Paul Walther
    Dinis P. Calado
    Boris Ferger
    Thomas Wirth
    Bernd Baumann
    Molecular Neurodegeneration, 12