3-Chloro-1,2-propanediol (3-MCPD), 2-chloro-1,3-propanediol (2-MCPD) and glycidyl esters in infant formula: a review

被引:18
|
作者
MacMahon, Shaun [1 ]
Beekman, Jessica [1 ]
机构
[1] US FDA, Ctr Food Safety & Appl Nutr, 5001 Campus Dr, College Pk, MD 20740 USA
关键词
FATTY-ACID ESTERS; MASS-SPECTROMETRY METHOD; ELAEIS-GUINEENSIS OIL; 3-CHLOROPROPANE-1,2-DIOL 3-MCPD; 3-MONOCHLOROPROPANEDIOL ESTERS; PROCESSING CONTAMINANTS; MCPD ESTERS;
D O I
10.1016/j.cofs.2019.05.005
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Methods and survey results for the detection of monochloropropanediol (MCPD) esters and glycidyl esters in infant formula will be reviewed. These process-induced contaminants have been shown to be potentially carcinogenic and/or genotoxic, making their occurrence in foods a potential concern. The presence of MCPD and glycidyl esters in infant formula is of specific concern, due to infants' low bodyweights and the potential that infant formula is the sole source of nutrition. Methods employing various approaches for the extraction and detection of these contaminants in infant formula will be reviewed, as will the results of occurrence studies and exposure estimates that have been conducted around the world.
引用
收藏
页码:67 / 72
页数:6
相关论文
共 50 条
  • [1] The redox sensor protein DJ-1 is oxidized by the food contaminants 3-chloro-1,2-propanediol (3-MCPD) and 2-chloro-1,3-propanediol (2-MCPD) in different rat tissues
    Buhrke, T.
    Voss, L.
    Briese, A.
    Stephanowitz, H.
    Krause, E.
    Braeuning, A.
    Lampen, A.
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2016, 389 (01) : S58 - S58
  • [2] Esters of 3-chloro-1,2-propanediol (3-MCPD) in vegetable oils: Significance in the formation of 3-MCPD
    Seefelder, W.
    Varga, N.
    Studer, A.
    Williamson, G.
    Scanlan, F. P.
    Stadler, R. H.
    [J]. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2008, 25 (04): : 391 - 400
  • [3] Assessment of intestinal absorption/metabolism of 3-chloro-1,2-propanediol (3-MCPD) and three 3-MCPD monoesters by Caco-2 cells
    Araujo, Magali
    Beekman, Jessica K.
    Mapa, Mapa S. T.
    MacMahon, Shaun
    Zhao, Yang
    Flynn, Thomas J.
    Flannery, Brenna
    Mossoba, Miriam E.
    Sprando, Robert L.
    [J]. TOXICOLOGY IN VITRO, 2020, 67
  • [4] Bioavailability of 3-monochloro-1,2-propanediol (3-MCPD) and 3-MCPD fatty acid esters
    Buhrke, T.
    Weisshaar, R.
    Lampen, A.
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2010, 381 : 85 - 85
  • [5] Migration studies of 3-chloro-1,2-propanediol (3-MCPD) in polyethylene extrusion-coated paperboard food packaging
    Pace, Gregory V.
    Hartman, Thomas G.
    [J]. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2010, 27 (06): : 884 - 891
  • [6] The food contaminant 3-chloro-1,2-propanediol (3-MCPD) induces oxidative stress in mouse kidneys, testes and brain
    Schultrich, K.
    Buhrke, T.
    Henderson, C.
    Wolf, R.
    Braeuning, A.
    Lampen, A.
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2018, 391 : S87 - S87
  • [7] Absorption and transport of 2-chloro-1,3-propanediol (2-MCPD) and its fatty acid esters by human intestinal Caco-2 cells
    Buhrke, Thorsten
    Kuhlmann, Jan
    Lampen, Alfonso
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2014, 387 : S33 - S33
  • [8] Occurrence of fatty acid esters of 3-MCPD, 2-MCPD and glycidol in infant formula
    Woehrlin, Friederike
    Fry, Hildburg
    Lahrssen-Wiederholt, Monika
    Preiss-Weigert, Angelika
    [J]. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2015, 32 (11): : 1810 - 1822
  • [9] Absorption and metabolism of the food contaminant 3-chloro-1,2-propanediol (3-MCPD) and its fatty acid esters by human intestinal Caco-2 cells
    Thorsten Buhrke
    Rüdiger Weißhaar
    Alfonso Lampen
    [J]. Archives of Toxicology, 2011, 85 : 1201 - 1208
  • [10] Absorption and metabolism of the food contaminant 3-chloro-1,2-propanediol (3-MCPD) and its fatty acid esters by human intestinal Caco-2 cells
    Buhrke, Thorsten
    Weisshaar, Ruediger
    Lampen, Alfonso
    [J]. ARCHIVES OF TOXICOLOGY, 2011, 85 (10) : 1201 - 1208