One-Pot Three-Component Synthesis of New β-Indole Derivatives in Gluconic Acid Aqueous Solution

被引：7

作者：

Yan, Nan ^{[1
,2
]}

Xia, Jianhui ^{[2
]}

Xiong, Yunkui ^{[1
]}

Xiong, Bin ^{[1
]}

Lin, Chunhua ^{[1
]}

Liao, Weilin ^{[2
]}

机构：

[1] Natl Monosaccharide Chem Synth Engn Res Ctr, Nanchang 330027, Peoples R China

[2] Jiangxi Normal Univ, Chem Res & Dev Ctr, Nanchang 330027, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 34卷 / 12期

关键词：

2,2-pentamethylene-1,3-dioxane-4,6-dione; gluconic acid aqueous solution; three-component reactions; beta-indole derivatives;

D O I：

10.6023/cjoc201406010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-pot three-component reactions of aldehydes with indole and 2,2-pentamethylene-1,3-dioxane-4,6-dione afforded thirteen kind's of 5-[(indol-3-yl)-methyl]-2,2-pentamethylene-1,3-dioxane-4,6-dione derivatives (beta-indole derivatives) in the presence of gluconic acid aqueous solution in 66.4%similar to 98.5% yields. The advantages of this protocol were mild reaction conditions, wide substrate scope, high yields and benign to environment, which afforded an effective method to synthesize beta-indole derivatives.

引用

页码：2487 / 2492

页数：6

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