IFN-γ, IL-10, ghrelin and nesfatin-1 levels in acute brucella patients IFN-γ, IL-10, ghrelin and nesfatin-1 in brucella

Aim: This study aimed to investigate gamma interferon (IFN-gamma), interleukin-10 (IL-10), ghrelin and nesfatin-1 levels in acute brucella patients and to evaluate the effect of combination of antimicrobial agents after therapy. Material and Methods: Patients were assigned to the Brucella-infected group if they had confirmed laboratory findings. Sixty brucella-infected patients and thirty healthy individuals were included in the study. Doxycycline-streptomycin (DOX-STR) and doxycycline-rifampicin (DOX-RIF) were used in the treatment of brucellosis. Results: Significantly increased IFN-gamma, IL-10 and ghrelin levels and decreased nesfatin-1 levels were determined in brucella patients compared with healthy controls (p < 0.001). After therapy, IFN-gamma, IL-10 and ghrelin levels were significantly lower, and nesfatin-1 levels were significantly higher compared to the pretreatment group, especially in (DOX-STR) regimen (p < 0.001). Discussion: It is thought that the rise of free oxygen radicals and the decrease in antioxidant capacity may play a role in the pathogenesis of brucellosis. In this study, the therapeutic power of antibiotic combinations was determined by monitoring inflammatory agents and ghrelin and nesfatin-1 levels measured before and after treatment in patients. Adding ghrelin and nesfatin-1 to effective treatment protocols for brucella will ameliorate their inflammatory status and antioxidant system.