Cytotoxicity, qualitative structure-activity relationship (QSAR), and anti-tumor activity of bismuth dithiocarbamate complexes

被引：82
|
作者：
Li, Hongyu
Lai, Chian Sing
Wu, Jinzhu
Ho, Paul C.
de Vos, Dick
Tiekink, Edward R. T.
机构：
[1] Univ Texas, Dept Chem, San Antonio, TX 78249 USA
[2] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
[3] Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore
[4] Pharmachem BV, NL-2003 RN Haarlem, Netherlands
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2007年 / 101卷 / 05期
关键词：
anti-tumor; bismuth complexes; dithicarbamate complexes; cytotoxicity;
D O I：
10.1016/j.jinorgbio.2007.01.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bismuth dithiocarbarnate complexes of general formula Bi(S2CNR2)(3) demonstrate potent in vitro cytotoxicity against a panel of seven human cancer cell lines-, a structure-activity relationship has been established. Potency exhibited by the R = Et (2) derivative, for example, is unrivalled by standard cancer drugs with the exception of paclitaxel. In vivo studies indicate a significant anti-tumor effect exerted by (2) against both OVCAR-3, an ovarian cancer cell line, and HT-29, a colon carcinoma cell line. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：809 / 816
页数：8
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