Synthesis of biaryls via decarboxylative Pd-catalyzed cross-coupling reaction

被引：199
|
作者：
Becht, Jean-Michel
Catala, Cedric
Le Drian, Claude
Wagner, Alain
机构：
[1] Univ Haute Alsace, Ecole Natl Super Chim, Lab Chim Organ & Bioorgan, CNRS,UMR 7015, F-68093 Mulhouse, France
[2] Novalyst Discovery, Bioparc, F-67405 Illkirch Graffenstaden, France
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 09期
关键词：
D O I：
10.1021/ol070495y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient route to biaryls via Pd-catalyzed decarboxylative cross-couplings of arene carboxylic acids and aryl iodides is reported. The PdCl(2)/AsPh(3) catalytic system in the presence of Ag(2)CO(3) in DMSO was found to be particularly efficient to perform this transformation. This reaction can be extended to the synthesis of various biaryls, including sterically hindered biaryls, with yields ranging from 58% to 90%.
引用
收藏
页码：1781 / 1783
页数：3
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