A lysosome-targeted near-infrared fluorescent probe for cell imaging of Cu2+

被引：21

作者：

Chen, Yin ^{[1
]}

Long, Zhiqing ^{[2
]}

Wang, Chengcheng ^{[1
]}

Zhu, Jingjing ^{[1
]}

Wang, Shasha ^{[1
]}

Liu, Yan ^{[1
]}

Wei, Peng ^{[1
]}

Yi, Tao ^{[1
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai Engn Res Ctr Nanobiomaterials & Regenerat, State Key Lab Modi ficat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China

[2] Shanxi Univ, Inst Mol Sci, Key Lab Chem Biol & Mol Engn Minist Educ, Key Lab Mat Energy Convers & Storage Shanxi Prov, Taiyuan 030006, Peoples R China

来源：

DYES AND PIGMENTS | 2022年 / 204卷

关键词：

Fluorescent probe; Methylene blue; Copper (II); Cell imaging; Lysosome; SELECTIVE DETECTION; COPPER; CHEMODOSIMETER; RHODAMINE; NAPHTHALIMIDE; PLATFORM; UNIT;

D O I：

10.1016/j.dyepig.2022.110472

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Cu2+ in lysosomes are closely related to some diseases such as Menke's syndrome, Wilson's diseases and Alzheimer's diseases. Although many fluorescent probes have been constructed for the detection of Cu2+ in lysosomes, the poor water solubility and short wavelength emission (lambda(em) < 600 nm) limit the application of these probes. To solve this problem, a fluorescent probe DHUCu-1 with near-infrared emission was designed and synthesized in this work. DHUCu-1 could detect Cu2+ in PBS solution (1% alcohol as co-solvent) with high sensitivity and good selectivity. Moreover, DHUCu-1 could target lysosomes and respond to Cu2+ in lysosomes. This probe thus can be used as a tool for the exploration of physiological functions of Cu2+ and the related diseases.

引用

页数：6

共 50 条

[1] A lysosome-targeted near-infrared fluorescent probe for imaging of acid phosphatase in living cells
Cai, Songtao
Liu, Chang
Jiao, Xiaojie
He, Song
Zhao, Liancheng
Zeng, Xianshun
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2020, 18 (06) : 1148 - 1154
[2] A lysosome-targeted near-infrared fluorescent probe for imaging endogenous cysteine (Cys) in living cells
Cai, Songtao
Liu, Chang
Jiao, Xiaojie
Zhao, Liancheng
Zeng, Xianshun
[J]. JOURNAL OF MATERIALS CHEMISTRY B, 2020, 8 (11) : 2269 - 2274
[3] Lysosome-targeted high resolution near-infrared fluorescent probe for low physiological pH imaging in vivo
Zhang, Tongxin
He, Xiaoyan
Zhou, Xiahuan
Du, Ling
Huang, Gang
Lu, Xiuhong
[J]. DYES AND PIGMENTS, 2023, 215
[4] Hierarchically self-assembled fluorescent nanoparticles for near-infrared lysosome-targeted imaging
Dong-Sheng, G.
[J]. CHINESE CHEMICAL LETTERS, 2018, 29 (12) : 1709 - 1710
[5] Hierarchically self-assembled fluorescent nanoparticles for near-infrared lysosome-targeted imaging
Dong-Sheng Guo
[J]. Chinese Chemical Letters, 2018, 29 (12) : 1709 - 1710
[6] A lysosome-targeted triazole near-infrared cyanine fluorescent probe for in vivo long-term cell tracking
Yu, Xianrong
Wu, Yu
Tang, Wei
Duan, Xinrui
[J]. ANALYST, 2023, 148 (20) : 5117 - 5123
[7] Upregulation of Formaldehyde in Parkinson?s Disease Found by a Near-Infrared Lysosome-Targeted Fluorescent Probe
Quan, Wei
Zhang, Guihua
Li, Yanxia
Song, Wenhui
Zhan, Jingting
Lin, Weiying
[J]. ANALYTICAL CHEMISTRY, 2023, 95 (05) : 2925 - 2931
[8] A Lysosome-Targeted Near-Infrared Fluorescent Probe with Excellent Water Solubility for Surgery Navigation in Breast Cancer
Wu, Yumei
Chen, Zhengjun
Shen, Dan
He, Zhiquan
Lv, Jiajia
Li, Hongyu
Yang, Mingyan
Tan, Jun
Yuan, Jianrong
Gao, Jie
Yuan, Zeli
[J]. ACS OMEGA, 2023, 8 (13): : 12481 - 12488
[9] A Ratiometric and near-Infrared Fluorescent Probe for Imaging Cu2+ in Living Cells and Animals
Guo, Rui
Wang, Qiuan
Lin, Weiying
[J]. JOURNAL OF FLUORESCENCE, 2017, 27 (05) : 1655 - 1660
[10] A Ratiometric and near-Infrared Fluorescent Probe for Imaging Cu2+ in Living Cells and Animals
Rui Guo
Qiuan Wang
Weiying Lin
[J]. Journal of Fluorescence, 2017, 27 : 1655 - 1660

← 1 2 3 4 5 →