Transition-metal-free photoredox intermolecular -arylation of ketones

被引：19
|
作者：
Pandey, Ganesh [1 ]
Tiwari, Sandip Kumar [1 ]
Budakoti, Asha [1 ]
Sahani, Pramod Kumar [1 ]
机构：
[1] Ctr Biomed Res CBMR, Mol Synth & Drug Discovery Lab, Sanjay Gandhi Postgrad Inst Med Sci Campus, Lucknow 226014, Uttar Pradesh, India
来源：
ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 17期
关键词：
CATALYZED ALPHA-ARYLATION; VISIBLE-LIGHT PHOTOCATALYSIS; C-H ARYLATION; NUCLEOPHILIC-SUBSTITUTION; REDUCTIVE ACTIVATION; BOND FORMATION; CARBONYL; ENONES; SALTS; FUNCTIONALIZATION;
D O I：
10.1039/c8qo00510a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
alpha-Arylation of ketones with electron rich arenes via sp(2)(C)-H has been achieved by the reaction of -phenylselanylketones using organic photoredox catalysis. The reaction proceeds via an -methylene ketone radical generated by sp(3)(C)-SePh activation. The developed method has been found to have broad substrate scope and is free from the use of pre-functionalized aromatics.
引用
收藏
页码：2610 / 2614
页数：5
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