Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc

被引：14
|
作者：
Lemoine, Remy C. [1 ]
Petersen, Ann C. [1 ]
Setti, Lina [1 ]
Baldinger, Thomas [1 ]
Wanner, Jutta [1 ]
Jekle, Andreas [2 ]
Heilek, Gabrielle [2 ]
deRosier, Andre [2 ]
Ji, Changhua [2 ]
Rotstein, David M. [1 ,2 ]
机构：
[1] Roche Palo Alto, Dept Med Chem, Palo Alto, CA 94304 USA
[2] Roche Palo Alto, Dept Viral Dis, Palo Alto, CA 94304 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 05期
关键词：
3-Amino-8-azabicyclo[3.2.1]octane; 5-Amino-3-azabicyclo[3.3.0]octane; CCR5; antagonist; Maraviroc; Replacement;
D O I：
10.1016/j.bmcl.2010.01.080
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the 3-amino-8-azabicyclo[3.2.1]octane found in the CCR5 antagonist maraviroc. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1674 / 1676
页数：3
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