Based on former conceptual models of vulnerability, this paper aims to improve the quantitative model for regional vulnerability assessment by analyzing in-depth the relation between vulnerability, exposure, coping capacity, and resilience. Taking the mountain settlements in the upper reaches of Min River, China, as a case study, the method of Contributing Weight Superposition (CWS) is applied in establishing both a model and a system for the vulnerability assessment of elements at risk. The CWS approach consists of 13 index factors including population, economic and road densities, building and farmland coverage, hazard-affected areas, urbanization rate, and GDP per capita. Accordingly, a debris flow hazard vulnerability zoning map was obtained and the assessment results show that the distribution of high and comparatively high vulnerability zones, where economic activities are considerably high, has a close correlation to the topography of the catchment and population characteristics. The results thus may serve as a pertinent guidance for settlement relocation, population distribution readjustment, and management to prevent and reduce hazards in the upper reaches of Min River and beyond.