The systemic estimation of the effect of photodynamic therapy of cancer

The effects of photodynamic therapy (PDT) of cancer needs objective estimation and its unification in experimental as well as in clinical studies. They must include not only macroscopical changes but also the complex of following morphological criteria: the level of direct tumour damage (direct necrosis and apoptosis); the level of indirect tumour damage (ischemic necrosis); the signs of vascular alterations; the local and systemic antiblastome resistance; the proliferative activity and malignant potential of survival tumour tissue. We have performed different regimes PDT using phthalocyanine derivatives. The complex of morphological methods (Ki-67, p53, c-myc, bcl-2) was used. Obtained results showed the connection of the titled morphological criteria with tumour regression.