1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione

被引：1
|
作者：
Pardali, Vasiliki [1 ]
Katsamakas, Sotirios [1 ]
Giannakopoulou, Erofili [1 ]
Zoidis, Grigoris [1 ]
机构：
[1] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Div Pharmaceut Chem, Athens 15771, Greece
来源：
MOLBANK | 2021年 / 2021卷 / 02期
关键词：
carbocyclic hydantoins; N-1 substituted hydantoin; spiro hydantoins; imidazolidine-2,4-diones; DFT calculations; stereochemistry; NMR; HRMS; GIAO; ring closing; SPIN COUPLING-CONSTANTS; 2ND ROW ATOMS; BASIS-SET; PERTURBATION-THEORY; HYDANTOIN; ANTICONVULSANT; DERIVATIVES; INHIBITORS; ANALOGS; DESIGN;
D O I：
10.3390/M1228
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5] decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields and no further purification. Therefore, the proposed method, with an overall yield of 60%, offers a facile pathway to the synthesis of N-1 monosubstituted spiro carbocyclic imidazolidine-2,4-diones (hydantoins), which constitute a privileged class of heterocyclic scaffolds with pharmacological interest.
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页数：7
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