A novel L-proline catalyzed Biginelli reaction:: One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones under solvent-free conditions

被引：101
|
作者：
Yadav, JS [1 ]
Kumar, SP [1 ]
Kondaji, G [1 ]
Rao, RS [1 ]
Nagaiah, K [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
CHEMISTRY LETTERS | 2004年 / 33卷 / 09期
关键词：
D O I：
10.1246/cl.2004.1168
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Novel efficient and simple synthetic protocol for the Biginelli reaction has been developed for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones in a one-pot three-component condensation of aldehydes, beta-dicarbonyl compounds, and urea or thiourea by using 10 mol % L-proline as the catalyst under solvent free condition.
引用
收藏
页码：1168 / 1169
页数：2
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