Genetics of Psoriasis

被引：73
|
作者：
Mahil, Satveer K. [1 ]
Capon, Francesca [2 ]
Barker, Jonathan N. [1 ]
机构：
[1] Kings Coll London, Guys & St Thomas NHS Fdn Trust, St Johns Inst Dermatol, Div Genet & Mol Med, London SE1 9RT, England
[2] Kings Coll London, Guys Hosp, Div Genet & Mol Med, London SE1 9RT, England
来源：
DERMATOLOGIC CLINICS | 2015年 / 33卷 / 01期
基金：
英国医学研究理事会;
关键词：
Psoriasis; Genetics; Genome-wide association studies; Stratification; GENOME-WIDE ASSOCIATION; GENERALIZED PUSTULAR PSORIASIS; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; SUSCEPTIBILITY LOCI; HLA-C; MISSING HERITABILITY; COMMON VARIANTS; INNATE IMMUNITY; LESIONAL SKIN; DOUBLE-BLIND;
D O I：
10.1016/j.det.2014.09.001
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Psoriasis is a common and debilitating immune-mediated skin disease with a complex genetic basis. Genetic studies have provided critical insights into the pathogenesis of disease. This article focuses on the results of genetic association studies, which provide evidence that psoriasis susceptibility genes are involved in innate and adaptive immunity and skin barrier functions. The potential for disease stratification and the development of more effective treatments with fewer side effects using genetic data are highlighted.
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页码：1 / +
页数：12
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