Solid phase synthesis of α-amino squaric acid-containing peptides

被引：3

作者：

Maeda, Kentaro ^{[1
]}

Kiniwa, Yu-ichi ^{[1
]}

Ohfune, Yasufumi ^{[1
]}

Ishiguro, Shinichi ^{[2
]}

Suzuki, Koichi ^{[2
]}

Murata, Kazuya ^{[3
]}

Matsuda, Hideaki ^{[3
]}

Shinada, Tetsuro ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Sci, Sumiyoshi Ku, Osaka 5588585, Japan

[2] Iwate Univ, Off Res Exchange, Morioka, Iwate 0208550, Japan

[3] Kinki Univ, Fac Pharm, Higashiosaka, Osaka 5778502, Japan

来源：

RSC ADVANCES | 2014年 / 4卷 / 92期

基金：

日本学术振兴会;

关键词：

IDENTIFICATION;

D O I：

10.1039/c4ra10442k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method has been developed for the synthesis of 3-(1-aminoalkyl)- 4-hydroxycyclobut-3-ene-1,2-dione [alpha-amino squaric acid (alpha-Asq)]-containing peptides using solid phase peptide synthesis according to an Fmoc protecting group strategy. FmocHN-Gly-[alpha-Asq]-Oi-Pr was successfully used as a coupling unit in this method, which allowed for the construction of alpha-Asq-containing hexapeptide libraries including Sq-Gly and Sq-Phe units using the Wang-resin. Peptides containing the alpha-Asq moiety exhibited inhibitory activity towards a digestive enzyme.

引用

页码：50639 / 50643

页数：5

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