Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered

被引：4
|
作者：
Contreras, Osvaldo [1 ,2 ]
Brandan, Enrique [3 ]
机构：
[1] Pontificia Univ Catolica Chile, Ctr Envejecimiento Regenerac, CARE Chile UC, Santiago, Chile
[2] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Biol Celular & Mol, Santiago, Chile
[3] Pontificia Univ Catolica Chile, Fac Biol Sci, Libertador Bernardo OHiggins 340, Santiago 8331150, Chile
来源：
JOURNAL OF CELL COMMUNICATION AND SIGNALING | 2017年 / 11卷 / 01期
关键词：
Fibrosis; PDGFR alpha; Fibro/adipogenic progenitors; Muscle regeneration; Polyadenylation; CONNECTIVE-TISSUE FIBROBLASTS; MUSCLE FIBROSIS; SKELETAL-MUSCLE; SATELLITE CELLS; PDGFR-ALPHA; MYOGENESIS; DYSTROPHY; INJURY;
D O I：
10.1007/s12079-016-0372-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
PDGFR alpha regulates several cellular processes, and exacerbated PDGF signaling cause fibrosis in different tissues. Different research groups have shown that fibro/adipogenic progenitors (FAPs) are responsible for pathological fibrosis found in skeletal muscle disorders. Rando's Lab describes that an intronic polyadenylation of Pdgfra regulates FAPs activity, and therefore fibrosis. This discovery opens a new potential target for treating fibrosis.
引用
收藏
页码：77 / 78
页数：2
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