Synthesis of 2-Substituted Pyrazolo[1,5-a]pyridines through Cascade Direct Alkenylation/Cyclization Reactions

被引：87

作者：

Mousseau, James J. ^{[1
]}

Fortier, Angelique ^{[1
]}

Charette, Andre B. ^{[1
]}

机构：

[1] Univ Montreal, Dept Chem, Stn Downtown, Montreal, PQ H3C 3J7, Canada

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

N-IMINOPYRIDINIUM YLIDES; CATALYZED DIRECT ARYLATION; SELECTIVE ALKENYLATION; AZAINDOLE DERIVATIVES; RECEPTOR; DISCOVERY; MECHANISM; OXIDES; FUNCTIONALIZATION; HYDROGENATION;

D O I：

10.1021/ol902710f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 2-substituted pyrazolo[1,5-a]pyridines from N-iminopyridinium ylides is described. These medicinally interesting compounds are formed through a cascade process involving a palladium-catalyzed direct alkenylation reaction followed by silver-mediated cyclization. The reaction can be performed with a wide range of electron-poor and electron-rich alkenyl iodides in good yields. This work represents perhaps the most direct route for the preparation of these compounds.

引用

页码：516 / 519

页数：4

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