Synthesis and functionalization of new tropanes designed for use as scaffolds in combinatorial chemistry

被引：1

作者：

Paparin, JL

Crévisy, C

Toupet, L

Grée, R

机构：

[1] ENSCR, UMR CNRS 6052, Lab Synth & Activat Biomol, F-35042 Rennes, France

[2] Univ Rennes 1, Grp Mat Condensee & Mat, F-35042 Rennes, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 2000卷 / 23期

关键词：

cycloadditions; alkaloids; combinatorial chemistry; scaffolds; tropanes;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The [4+3] cycloaddition reaction between alkyloxycarbonyl-substituted pyrroles and alpha,alpha'-dibromo ketones in the presence of diethylzinc has been extended to a wide range of substrates. The functionalization of the resulting tropanes has been studied. It is demonstrated that such tropanes represent potentially useful scaffolds.

引用

页码：3909 / 3918

页数：10

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