Toward a Molecular-Genetic Classification of Spitzoid Neoplasms

被引：24

作者：

Tetzlaff, Michael T. ^{[1
,2
]}

Reuben, Alexandre ^{[3
]}

Billings, Steven D. ^{[4
]}

Prieto, Victor G. ^{[1
,5
]}

Curry, Jonathan L. ^{[1
,5
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Sect Dermatopathol, 1515 Holcombe Blvd,Unit 85, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Translat & Mol Pathol, 1515 Holcombe Blvd,Unit 85, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, 1515 Holcombe Blvd, Houston, TX 77030 USA

[4] Cleveland Clin, Dept Pathol, 9500 Euclid Ave L25, Cleveland, OH 44106 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Dermatol, 1515 Holcombe Blvd,Unit 85, Houston, TX 77030 USA

来源：

CLINICS IN LABORATORY MEDICINE | 2017年 / 37卷 / 03期

关键词：

Spitz nevus; Atypical Spitz tumor; Spitzoid melanoma; HRAS; BAP1; Comparative genomic hybridization; Fluorescence in situ hybridization; Telomerase promoter; IN-SITU HYBRIDIZATION; TERT PROMOTER MUTATIONS; EPITHELIOID CELL NEVI; MELANOCYTIC TUMORS; BAP1; EXPRESSION; BLUE NEVUS; DIFFERENTIAL-DIAGNOSIS; MALIGNANT-MELANOMA; THYROID CARCINOMAS; ATYPICAL VARIANTS;

D O I：

10.1016/j.cll.2017.05.003

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The histopathologic spectrum of Spitzoid neoplasms includes Spitz nevi, atypical Spitz tumors, and Spitzoid melanomas. Advances in molecular genetics have evolved to the point that Spitzoid lesions can now be reasonably classified according to their distinctive molecular-genetic alterations: Spitzoid lesions with (1) 11p amplification and/or HRAS mutations; (2) isolated loss of 6q23 by fluorescence in situ hybridization (FISH); (3) homozygous deletion of 9p21 by FISH; (4) BAP1 loss and BRAFV600 E mutation; (5) translocations involving any of a number of different oncogenic kinase drivers, including ROS1, ALK, NTRK1, NTRK3, MET, BRAF, and RET; and (6) TERT promoter mutations.

引用

页码：431 / +

页数：19

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