Lack of mitochondrial depolarization by oxidative stress is associated with resistance to buthionine sulfoximine in acute lymphoblastic leukemia cells

被引：0
|
作者：
Goto, Hiroaki [1 ]
Yanagimachi, Masakatsu [1 ]
Kajiwara, Ryosuke [1 ]
Kuroki, Fumiko [1 ]
Yokota, Shumpei [1 ]
机构：
[1] Yokohama City Univ Med, Dept Pediat, Kanazawa Ku, Yokohama, Kanagawa 2360044, Japan
来源：
LEUKEMIA RESEARCH | 2007年 / 31卷 / 09期
关键词：
acute lymphoblastic leukemia; glutathione; buthionie sulfoximine; oxidative stress; mitochondria;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Raised intracellular glutathione is one characteristics of high-risk childhood acute lymphoblastic leukemia (ALL). Depletion of glutathione by buthionine sulfoximine (BSO) has been reported to be toxic against some cancer cells. To assess the role of glutathione in ALL, the toxicity of BSO was studied in B-precursor ALL cell lines. BSO increased oxidative stress equally in all cell lines; however mitochondrial depolarization was observed only in BSO-sensitive cells. BSO up-regulated Bcl-2 protein, and antagonized the anti-ALL effect of prednisolone in BSO-resistant cells. A lack of mitochondrial death-signal activation by oxidative stress seemed to be associated with BSO-resistance in ALL. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1293 / 1301
页数：9
相关论文
共 50 条
  • [1] Reduction of oxidative stress promotes daunorubicin resistance in acute lymphoblastic leukemia cells
    Sheng, Xia
    Tucci, Jonathan
    Mittelman, Steven D.
    CANCER RESEARCH, 2015, 75
  • [2] The responses of Ht22 cells to oxidative stress induced by buthionine sulfoximine (BSO)
    Jun Chen
    Andrea Small-Howard
    Amy Yin
    Marla J Berry
    BMC Neuroscience, 6
  • [3] The responses of Ht22 cells to oxidative stress induced by buthionine sulfoximine (BSO)
    Chen, J
    Small-Howard, A
    Yin, A
    Berry, MJ
    BMC NEUROSCIENCE, 2005, 6 (1)
  • [4] BIMELis a key effector molecule in oxidative stress-mediated apoptosis in acute myeloid leukemia cells when combined with arsenic trioxide and buthionine sulfoximine
    Yukie Tanaka
    Takayuki Komatsu
    Hiroko Shigemi
    Takahiro Yamauchi
    Yutaka Fujii
    BMC Cancer, 14
  • [5] BIMEL is a key effector molecule in oxidative stress-mediated apoptosis in acute myeloid leukemia cells when combined with arsenic trioxide and buthionine sulfoximine
    Tanaka, Yukie
    Komatsu, Takayuki
    Shigemi, Hiroko
    Yamauchi, Takahiro
    Fujii, Yutaka
    BMC CANCER, 2014, 14
  • [6] OXIDATIVE STRESS INFLUENCE HYDROXYMETHYLATION STATUS IN ACUTE LYMPHOBLASTIC LEUKEMIA CELLS IN VITRO
    Goncalves, A.
    Leite, J.
    Ferreira, M.
    Guarino, P.
    Domingues, C.
    Alves, R.
    Sarmento-Ribeiro, A.
    HAEMATOLOGICA, 2013, 98 : 495 - 495
  • [7] Oxidative stress: MDA as biomarker in acute lymphoblastic leukemia
    Almeida, Mariana Bortholazzi
    Madeira, Tiago Bervelieri
    Marques, Leticia Aparecida
    Amarante, Marla Karine
    Nixdorf, Suzana Lucy
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
  • [8] Buthionine Sulfoximine Promotes Methylglyoxal-Induced Apoptotic Cell Death and Oxidative Stress in Endothelial Cells
    Takahashi, Kyohei
    Tatsunami, Ryosuke
    Oba, Tatsuya
    Tampo, Yoshiko
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2010, 33 (04) : 556 - 560
  • [9] Acute Lymphoblastic Leukemia (ALL) resistance/sensitivity to glucocorticoid induced apoptosis: the role of oxidative stress
    Berrou, Ilhem
    Qattan, Malak
    Andreou, Kleopatra
    Krstic-Demonacos, Marija
    Demonacos, Costas
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2012, 30 : S33 - S33
  • [10] Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress
    Burt, Richard
    Dey, Aditi
    Aref, Sarah
    Aguiar, Melanie
    Akarca, Ayse
    Bailey, Katharine
    Day, William
    Hooper, Steven
    Kirkwood, Amy
    Kirschner, Kristina
    Lee, Soo-Wah
    Lo Celso, Cristina
    Manji, Jiten
    Mansour, Marc R.
    Marafioti, Teresa
    Mitchell, Rachel J.
    Muirhead, Robert C.
    Ng, Kenton Cheuk Yan
    Pospori, Constandina
    Puccio, Ignazio
    Zuborne-Alapi, Krisztina
    Sahai, Erik
    Fielding, Adele K.
    BLOOD, 2019, 134 (17) : 1415 - 1429
12345