Iodine-restricted food versus pharmacological therapy in the management of feline hyperthyroidism: A controlled trial in 34 cats

被引:4
|
作者
Grossi, Giorgio [1 ]
Zoia, Andrea [2 ]
Palagiano, Paola [3 ]
Leoni, Nadia [4 ]
Bubini-Regini, Federica
Malerba, Eleonora [1 ]
Peli, Angelo [1 ]
Biagi, Giacomo [1 ]
Fracassi, Federico [1 ]
机构
[1] Univ Bologna, Dept Vet Med Sci, Bologna, Italy
[2] San Marco Vet Clin, Padua, Italy
[3] Meda Vet Clin, Meda, Italy
[4] San Siro Vet Clin, Milan, Italy
关键词
Iodine-restricted food; Liver enzymes; Methimazole; Pluronic lecithin organogel; Thyroxine; TRANSDERMAL METHIMAZOLE; RENAL-FUNCTION; EFFICACY; SAFETY;
D O I
10.4314/ovj.v9i3.3
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Background: Hyperthyroidism is a common endocrinopathy of middle-aged and elderly cats. Dietary treatment has been proposed as an alternative to traditional therapies. Aim: The aim of this prospective study was to compare the efficacy of iodine-restricted food versus pharmacological therapy with methimazole in client-owned cats with hyperthyroidism. Methods: Indoor cats with newly diagnosed hyperthyroidism (consistent clinical signs and serum total thyroxine concentration greater than 50 nmo1/1) were assigned to one of three groups: (A) received an iodine-restricted food as a single therapy; (B) received transdermal methimazole in pluronic lecithin organogel; and (C) received oral methimazole. In all groups, clinical parameters, biochemistry, and serum total thyroxine were evaluated at baseline and 10, 30, 60, and 90 days after treatment began. Results: Thirty-four cats were enrolled in the study (group A: n = 14; group B: n = 11; group C: n = 9). No significant differences were found between groups at diagnosis for signalment, clinical and laboratory findings, including serum total thyroxine concentrations. In all the groups, serum total thyroxine concentration decreased significantly following the baseline measurement. After 90 days of treatment, serum creatinine increased significantly only in the methimazoletreated groups. Liver enzyme activities decreased significantly only in group B, while no significant decreases were detected in groups A and C at any time. Conclusion: These results suggest that iodine-restricted food is effective at reducing the total thyroxine concentration in the serum of hyperthyroid cats. Moreover. the iodine-restricted food did not cause any increase in senun creatinine concentrations and failed to improve liver enzy mes abnormalities. These findings could indicate a persistent hyperthyroid state in cats treated with iodine-restricted food despite normalization of serum total thyroxine concentrations.
引用
收藏
页码:196 / 204
页数:9
相关论文
共 50 条
  • [1] Effects of an iodine-restricted food on client-owned cats with hyperthyroidism
    van der Kooij, Marieke
    Becvarova, Iveta
    Meyer, Hein P.
    Teske, Erik
    Kooistra, Hans S.
    [J]. JOURNAL OF FELINE MEDICINE AND SURGERY, 2014, 16 (06) : 491 - 498
  • [2] Effect of Feeding an Iodine-Restricted Diet in Cats with Spontaneous Hyperthyroidism
    Hui, T. Y.
    Bruyette, D. S.
    Moore, G. E.
    Scott-Moncrieff, J. C.
    [J]. JOURNAL OF VETERINARY INTERNAL MEDICINE, 2015, 29 (04): : 1063 - 1068
  • [3] A Restricted Iodine Food Reduces Circulating Thyroxine Concentrations in Cats with Hyperthyroidism
    Fritsch, Dale A.
    Allen, Timothy A.
    Dodd, Chadwick E.
    Wedekind, Karen J.
    Sixby, Kristin A.
    [J]. INTERNATIONAL JOURNAL OF APPLIED RESEARCH IN VETERINARY MEDICINE, 2014, 12 (01): : 24 - 32
  • [4] One-year study evaluating efficacy of an iodine-restricted diet for the treatment of moderate-to-severe hyperthyroidism in cats
    Loftus, John P.
    DeRosa, Sage
    Struble, Angela M.
    Randolph, John F.
    Wakshlag, Joseph J.
    [J]. VETERINARY MEDICINE-RESEARCH AND REPORTS, 2019, 10 : 9 - 16
  • [5] A randomized controlled trial of medical versus surgical therapy in the management of obesity
    O'Brien, P
    Dixon, J
    Laurie, C
    Skinner, S
    Proietto, J
    [J]. OBESITY RESEARCH, 2004, 12 : A33 - A33
  • [6] Meta-Analysis of Randomized Controlled Trials Comparing the Efficacy of Radioactive Iodine Monotherapy versus Radioactive Iodine Therapy and Adjunctive Lithium for the Treatment of Hyperthyroidism
    Ahmed, Fahad Wali
    Kirresh, Omar Zuhair
    Majeed, Muhammad Shakeel
    Iftikhar, Mawara
    Sajid, Muhammad Shafique
    [J]. ENDOCRINE RESEARCH, 2021, 46 (04) : 160 - 169
  • [7] Self-management versus conventional management of oral anticoagulant therapy: A randomized, controlled trial
    Christensen, Thomas D.
    Maegaard, Marianne
    Sorensen, Henrik T.
    Hjortdal, Vibeke E.
    Hasenkam, J. Michael
    [J]. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2006, 17 (04) : 260 - 266
  • [8] Pharmacological versus electroconvulsive therapy in treatment resistant bipolar disorder depression: study protocol of a randomized controlled trial
    Kessler, U.
    Vaaler, A. E.
    Schoyen, H.
    Oedegaard, K. J.
    Bergsholm, P.
    Andreassen, O. A.
    Malt, U. F.
    Morken, G.
    [J]. BIPOLAR DISORDERS, 2011, 13 : 61 - 61
  • [9] Pilot randomized controlled trial of restricted versus liberal crystalloid fluid management in pediatric post-operative and trauma patients
    Vincent P. Duron
    Rika Ichinose
    Latoya A. Stewart
    Chloe Porigow
    Weijia Fan
    Jeanne M. Rubsam
    Steven Stylianos
    Nicolino V. Dorrello
    [J]. Pilot and Feasibility Studies, 9
  • [10] Randomized Controlled Trial of Liberal Versus Restricted Fluid Management in Patients Undergoing Pancreatectomy (vol 264, pg 591, 2016)
    Grant, F.
    Brennan, M. F.
    Allen, P. J.
    [J]. ANNALS OF SURGERY, 2018, 267 (03) : E61 - E61