The Relationship between Adipokines, Metabolic Parameters and Insulin Resistance in Patients with Metabolic Syndrome and Type 2 Diabetes

被引：58
|
作者：
Lee, J. M. [1 ]
Kim, S. R. [1 ]
Yoo, S. J. [1 ]
Hong, O. K. [1 ]
Son, H. S. [1 ]
Chang, S. A. [1 ]
机构：
[1] Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul 130709, South Korea
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2009年 / 37卷 / 06期
关键词：
ADIPOKINES; METABOLIC SYNDROME; TYPE; 2; DIABETES; INSULIN RESISTANCE; SUBCUTANEOUS ADIPOSE-TISSUE; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; WEIGHT-LOSS; ADIPONECTIN RATIO; TNF-ALPHA; OBESE; EXPRESSION; GLUCOSE; LEPTIN;
D O I：
10.1177/147323000903700616
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
This study was designed to investigate the relationship between adipokines in metabolic syndrome and insulin resistance. Sixty male and female subjects with or without metabolic syndrome and type 2 diabetes were included. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Compared with lean control subjects, patients with metabolic syndrome and type 2 diabetes had lower circulating levels of total adiponectin and high molecular weight (HMW) adiponectin, and higher levels of leptin and interleukin-6 (IL-6). Total and HMW adiponectin and the adiponectin/leptin (A/L) ratio were negatively correlated with HOMA-IR. After adjusting for age and sex, leptin, IL-6 and tumour necrosis factor-et (TNF-alpha) were positively correlated with HOMA-IR. After also adjusting for body mass index, HOMA-IR was found to be independently associated with leptin, A/L ratio and TNF-a levels. In conclusion, decreased total adiponectin and HMW adiponectin and increased leptin and IL-6 levels are characteristic of patients with metabolic syndrome and type 2 diabetes.
引用
收藏
页码：1803 / 1812
页数：10
相关论文
共 50 条
  • [1] Relationship between the metabolic syndrome and the insulin resistance in adults with type 2 diabetes risk
    Ignacio Coniglio, Raul
    Ferraris, Roberto
    Prieto, Andrea
    Alberto Vasquez, Luis
    Garro, Sandra
    Antonio Tripodi, Marco
    Maria Salgueiro, Ana
    Carlos Otero, Juan
    Marcela Malaspina, Maria
    Montiel, Hugo
    [J]. ACTA BIOQUIMICA CLINICA LATINOAMERICANA, 2013, 47 (01): : 25 - 35
  • [2] INSULIN RESISTANCE IN PATIENTS WITH TYPE 1 DIABETES: RELATIONSHIP WITH METABOLIC AND INFLAMMATORY PARAMETERS
    Bulum, Tomislav
    Duvnjak, Lea
    [J]. ACTA CLINICA CROATICA, 2013, 52 (01) : 43 - 51
  • [3] The Impact of Type 2 Diabetes on Circulating Adipokines in Patients with Metabolic Syndrome
    Schindler, Karin
    Vila, Greisa
    Hoppichler, Friedrich
    Lechleitner, Monika
    Luger, Anton
    Anderwald, Christian
    Hoefler, Juergen
    Tomasec, Goran
    Kautzky-Willer, Alexandra
    Ludvik, Bernhard
    [J]. OBESITY FACTS, 2012, 5 (02) : 270 - 276
  • [4] ADIPOKINES - Significance for insulin resistance and the metabolic syndrome
    Scherer, PE
    [J]. FASEB JOURNAL, 2006, 20 (05): : A1335 - A1336
  • [5] RELATIONSHIP BETWEEN METABOLIC SYNDROME AND METABOLIC SYNDROME SCORE AND INSULIN RESISTANCE AND BETA CELL FUNCTION IN KOREAN ADULTS WITH TYPE 2 DIABETES MELLITUS
    Yoon, Hyun
    Kim, Sung Gil
    Kim, Gwang Seok
    Park, Bu Yeon
    [J]. ACTA MEDICA MEDITERRANEA, 2016, 32 (05): : 1697 - 1704
  • [6] VASOMOTOR DYSFUNCTION AND ALTERATIONS OF ADIPOKINES IN METABOLIC SYNDROME PATIENTS WITH INSULIN RESISTANCE
    Mikelsone, Indra
    Jurka, Antra
    Bormane, Inga
    Reihmane, Dace
    Balode, Liga
    Aivars, Juris Imants
    Tretjakovs, Peteris
    [J]. JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009, 59 : 505 - 505
  • [7] The role of adipokines in the development of metabolic syndrome and type 2 diabetes
    Tobe, K
    Kadowaki, T
    [J]. CHEMISTRY AND PHYSICS OF LIPIDS, 2005, 136 (02) : 95 - 96
  • [8] Increased Adipose Tissue Insulin Resistance in Metabolic Syndrome: Relationship to Circulating Adipokines
    Adams-Huet, Beverley
    Devaraj, Sridevi
    Siegel, David
    Jialal, Ishwarlal
    [J]. METABOLIC SYNDROME AND RELATED DISORDERS, 2014, 12 (10) : 503 - 507
  • [9] Adiponectin, insulin resistance and clinical expression of the metabolic syndrome in patients with Type 2 diabetes
    Mojiminiyi, O. A.
    Abdella, N. A.
    Al Arouj, M.
    Ben Nakhi, A.
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2007, 31 (02) : 213 - 220
  • [10] Adiponectin, insulin resistance and clinical expression of the metabolic syndrome in patients with Type 2 diabetes
    O A Mojiminiyi
    N A Abdella
    M Al Arouj
    A Ben Nakhi
    [J]. International Journal of Obesity, 2007, 31 : 213 - 220
12345