Correction pen as a hydrophobic/lipophobic barrier plotter integrated with paper-based chips and a mini UV-torch to implement all-in-one device for determination of carbazochrome

被引：9

作者：

El-Shaheny, Rania ^{[1
,2
]}

Al-Khateeb, Lateefa A. ^{[3
]}

El Hamd, Mohamed A. ^{[4
,5
]}

El-Maghrabey, Mahmoud ^{[1
,6
]}

机构：

[1] Mansoura Univ, Dept Pharmaceut Analyt Chem, Fac Pharm, Mansoura 35516, Egypt

[2] Nagasaki Univ, Grad Sch Biomed Sci, Course Pharmaceut Sci, Nagasaki, Japan

[3] King Abdulaziz Univ, Dept Chem, Fac Sci, Jeddah, Saudi Arabia

[4] South Valley Univ, Dept Pharmaceut Analyt Chem, Fac Pharm, Qena 83523, Egypt

[5] Shaqra Univ, Dept Pharmaceut Sci, Coll Pharm, Al Dawadmi 11961, Shaqra, Saudi Arabia

[6] Nagasaki Univ, Grad Sch Biomed Sci, Dept Pharmaceut Analyt Chem, Course Pharmaceut Sci, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan

来源：

ANALYTICA CHIMICA ACTA | 2021年 / 1172卷

关键词：

Paper-based; All-in-one device; Smartphone; Carbazochrome; Graphene quantum dots; Fluorescence; SODIUM-SULFONATE; HUMAN PLASMA; FLUORESCENCE; VALIDATION; IONIZATION; ACID; HPLC;

D O I：

10.1016/j.aca.2021.338684

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

ng/detection zone and good %recovery (100.0 +/- 0.4). The reliability of the device was ascertained by favorable statistical comparison with the analogous optimized conventional fluorimetry method and a reference HPLC method. The device has been successfully applied for versatile quantitation of carbazochrome in tablets and on manufacturing equipment surfaces with excellent recoveries. The device offers many green aspects that definitely assist the implementation of the sustainability concept to analytical laboratories. The cost-efficiency, reliability, and ease of fabrication as well as the greenness and user The design of a cheap, simple, and handy sensing system for rapid quantitation of pharmaceuticals becomes mandatory to ease drug development procedures, quality control, health care, etc. This work describes a simple, innovative, and easily manufactured paper-based device using a correction pen as a plotter for hydrophobic/lipophobic barriers and graphene quantum dots for recognition and quantifi-cation of the hemostatic drug carbazochrome, via fluorescence turn-off mechanism mediated by the inner filter effect. A smartphone-based all-in-one device fitted with an inexpensive 365 nm flashlight as a UV light source and a free image processing software was developed for rapid and reliable interpretation of the fluorescence change from the paper-based device upon introduction of the drug. The simple and convenient steps permit the analysis of many samples in a very short time. The smartphone-based all-in-one device featured excellent sensitivity for carbazochrome with a limit of detection equals to 12ng/detection zone and good %recovery (100.0 +/- 0.4). The reliability of the device was ascertained by favorable statistical comparison with the analogous optimized conventional fluorimetry method and a reference HPLC method. The device has been successfully applied for versatile quantitation of carbazochrome in tablets and on manufacturing equipment surfaces with excellent recoveries. The device offers many green aspects that definitely assist the implementation of the sustainability concept to analytical laboratories. The cost-efficiency, reliability, and ease of fabrication as well as the greenness and user friendship qualify the device for wide application in low-income communities. (c) 2021 Elsevier B.V. All rights reserved.

引用

页数：16