Statherin levels in saliva of patients with precancerous and cancerous lesions of the oral cavity: a preliminary report

被引：32

作者：

Contucci, AM

Inzitari, R

Agostino, S

Vitali, A

Fiorita, A

Cabras, T

Scarano, E

Messana, I

机构：

[1] Univ Cattolica Sacro Cuore, Dept Otolaryngol, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Dept Biochem & Clin Biochem, I-00168 Rome, Italy

[3] Univ Cagliari, Dept Appl Sci Biosyst, Cagliari, Italy

来源：

ORAL DISEASES | 2005年 / 11卷 / 02期

关键词：

statherin; saliva; oral diseases;

D O I：

10.1111/j.1601-0825.2004.01057.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

OBJECTIVE: The aim of this study was to measure concentration of human salivary statherin in patients with oral cavity pathologies and salivary gland diseases. SUBJECTS AND METHODS: Levels of statherin were analysed with High Performance Liquid Chromatography (HPLC) in following groups of subjects: group A: 24 patients with neoplastic diseases of salivary glands, group B: 13 patients with inflammatory lesions of salivary glands, group C: 13 patients with precancerous and cancerous lesions of the oral cavity excluding salivary gland tumors, group D: 20 healthy volunteers (control group). RESULTS: Our preliminary data indicated a sensible reduction of the statherin level in the saliva of patients with precancerous and cancerous lesions of the oral cavity (group C) compared with the healthy subjects (group D). The statherin levels are not significantly reduced either in the inflammatory (group B) or in the salivary glands tumours (group A), compared with the healthy subjects (group D). CONCLUSION: Statherin could play a protective effect in oral cavity in association with its other functions.

引用

页码：95 / 99

页数：5

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