Facile fabrication of cupric ion-carbon quantum dots as tumor-specific nanotheranostics for cuprous ion-mediated chemodynamic therapy and real-time fluorescence imaging

被引：8

作者：

Li, J. ^{[1
,2
]}

Liu, P. ^{[1
,2
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat G, Lanzhou 730000, Peoples R China

来源：

MATERIALS TODAY CHEMISTRY | 2022年 / 26卷

关键词：

Nanotheranostics; Tumor-specific; Carbon quantum dots; Copper; Chemodynamic therapy; Fluorescence imaging;

D O I：

10.1016/j.mtchem.2022.101040

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carbon quantum dots (CDs) have attracted intense interest in biomedical imaging. However, their very small diameter and non-characteristic fluorescence limit the practical application. Herein, Cu(II)-complexed CDs (Cu(II)-CDs NPs) have been designed via facile complexing CDs with Cu(II) ions, for the tumor intracellular glutathione-activated cuprous ion-mediated chemodynamic therapy and real -time fluorescence imaging. They were quite stable in both neutral and weakly acidic solutions even with lower glutathione (GSH)-level and dilution, emitting very weak fluorescence, while as in the simulated intracellular microenvironment, slight or strong fluorescence was emitted in the normal or tumor cells, respectively. Especially, they could release CDs and Cu(I) ions due to GSH-triggered disin-tegration. Such features make them promising nanotheranostics in tumor treatment, and the tumor-specific cuprous ion-mediated chemodynamic therapy and real-time fluorescence imaging were revealed in the in vitro cellular tests.(c) 2022 Elsevier Ltd. All rights reserved.

引用

页数：9