Regiospecific Three-Component Aminofluorination of Olefins via Photoredox Catalysis

被引：54

作者：

Mo, Jia-Nan ^{[1
]}

Yu, Wan-Lei ^{[1
]}

Chen, Jian-Qiang ^{[1
]}

Hu, Xiu-Qin ^{[1
]}

Xu, Peng-Fei ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 15期

关键词：

C-H FUNCTIONALIZATION; INTERMOLECULAR AMINOFLUORINATION; VICINAL DIFUNCTIONALIZATION; ALKENE FUNCTIONALIZATION; BETA-FLUOROAMINES; ACID; DERIVATIVES; LY503430; FLUORIDE; POTENTIATOR;

D O I：

10.1021/acs.orglett.8b01760

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct visible-light-mediated aminofluorination of styrenes has been developed with high regioselectivity. Shelf stable N-Ts-protected 1-aminopyridine salt was used as the nitrogen-radical precursor, and the commercially available hydrogen fluoride-pyridine was used as the nucleophilic fluoride source. The synthesis of an analogue of LY503430 was performed to demonstrate the synthetic value of this strategy.

引用

页码：4471 / 4474

页数：4

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