Reactions of 1,2,4-triazole derivatives with a "model" thiirane

被引：2
|
作者：
Klen, E. E. [1 ]
Khaliullin, F. A. [1 ]
机构：
[1] Bashkir State Med Univ, Ufa 450000, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 46卷 / 05期
关键词：
N-OXIDES; DRUGS;
D O I：
10.1134/S1070428010050155
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reactions of 3-mono- and 3,5-disubstituted 1,2,4-triazoles with a "model" thiirane, 8-bromo-1,3-dimethyl-7-(thiiran-2-ylmethyl)-3,7-dihydro-1H-purine-2,6-diones proceed at the positions N(1) and N(2) of the triazole ring and yield 7-(5-R-3-R'-1,2,4-triazol-1-yl)methyl- and/or 7-(5-R'-3-R-1,2,4-triazol-1-yl)methyl-1,3-dimethyl-6,7-dihydro[1,3]thiazolo[2,3-f]-purine-2,4-(1H,3H)-diones. 3-Methylsulfonyl-1,2,4-triazole reacted regiospecifically at the position N(1) forming 1,3-dimethyl-7-[(3-methyl-sulfonyl-1,2,4-triazole-1-yl)-methyl]-6,7-dihydro[1,3]thiazolo-[2,3-f]purine-2,4(1H,3H)-dione.
引用
收藏
页码：685 / 688
页数：4
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