CDr10b inhibits the expression of cyclooxygenase-2 and inducible nitric oxide synthase induced by lipopolysaccharide

被引：2

作者：

Gu, Gyo-Jeong ^{[1
]}

Lim, Se-Jin ^{[2
]}

Ahn, Sang-il ^{[1
]}

Lee, Sung-Chan ^{[3
]}

Chang, Young-Tae ^{[4
,5
,6
]}

Choi, Tae Hyun ^{[7
]}

Kim, Byoung Soo ^{[7
]}

Eom, Yong-Bin ^{[2
]}

Lee, Na Kyung ^{[2
]}

Youn, Hyung-Sun ^{[1
,2
]}

机构：

[1] Soonchunhyang Univ, Coll Med Sci, Dept Med Sci, Chungnam 336745, Asan Si, South Korea

[2] Soonchunhyang Univ, Coll Med Sci, Dept Biomed Lab Sci, Chungnam 336745, Asan Si, South Korea

[3] Aptabio Therapeut Inc, Yongin 446908, South Korea

[4] Natl Univ Singapore, Inst Life Sci, Dept Chem, Singapore 117543, Singapore

[5] Natl Univ Singapore, Inst Life Sci, MedChem Program, Singapore 117543, Singapore

[6] ASTAR, Singapore Bioimaging Consortium SBIC, Lab Bioimaging Probe Dev, Singapore 138667, Singapore

[7] Korea Inst Radiol & Med Sci, Dept Imaging, Seoul 139706, South Korea

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2014年 / 742卷

基金：

新加坡国家研究基金会;

关键词：

Inflammation; Nuclearfactor-kappa B; Cyclooxygenase-2; Inducible nitric oxide synthase; CDr10b; TOLL-LIKE RECEPTOR; NF-KAPPA-B; SIGNALING PATHWAYS; GENE-EXPRESSION; INNATE IMMUNITY; ACTIVATION; TLR4; HOMODIMERIZATION; PHYTOCHEMICALS; RECOGNITION;

D O I：

10.1016/j.ejphar.2014.08.036

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pathophysiological processes of inflammation can lead to a host of diseases, such as periodontitis, atherosclerosis, rheumatoid arthritis, and even cancer. The dysregulated inducible nitric oxide synthase ( iNOS) and cyclooxygenase-2 ( COX- 2) activation play important roles in the development of certain inflammatory diseases. Here, we investigated the effects of CDr10b which is originally developed for a microglia staining probe on inflammation, by modulating NF-kappa B activation and iNOS and COX-2 expression induced by lipopolysaccharide (LPS) in murine macrophages. The CDr10b suppressed NF-kappa B activation and iNOS and COX-2 expression induced by LPS. All the results suggest that CDr10b is a promising novel agent for the treatment of inflammatory diseases. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：42 / 46

页数：5

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