Clinical Trial Registration Patterns and Changes in Primary Outcomes of Randomized Clinical Trials From 2002 to 2017

被引：3

作者：

Lamberink, Herm J. ^{[1
,2
]}

Vinkers, Christiaan H. ^{[3
,4
]}

Lancee, Michelle ^{[5
]}

Damen, Johanna A. A. ^{[6
]}

Bouter, Lex M. ^{[7
,8
]}

Otte, Willem M. ^{[2
,9
]}

Tijdink, Joeri K. ^{[8
,10
]}

机构：

[1] Haaglanden Med Ctr, Dept Neurol, The Hague, Netherlands

[2] Univ Med Ctr UMC Utrecht, Dept Child Neurol, UMC Utrecht Brain Ctr, Utrecht, Netherlands

[3] Vrije Univ, Dept Psychiat, Amsterdam Univ Med Ctr, Amsterdam Neurosci, Amsterdam, Netherlands

[4] Vrije Univ, Dept Anat & Neurosci, Amsterdam Univ Med Ctr, Amsterdam Neurosci, Amsterdam, Netherlands

[5] Univ Med Ctr Utrecht, Dept Psychiat, UMC Utrecht Brain Ctr, Utrecht, Netherlands

[6] Univ Utrecht, Cochrane Netherlands, Julius Ctr Hlth Sci & Primary Care, Univ Med Ctr Utrecht, Utrecht, Netherlands

[7] Amsterdam Univ Med Ctr, Dept Epidemiol & Data Sci, Amsterdam, Netherlands

[8] Vrije Univ, Dept Philosophy, Fac Humanities, Amsterdam, Netherlands

[9] Univ Med Ctr Utrecht, Biomed MR Imaging & Spect, Ctr Image Sci, Utrecht, Netherlands

[10] Amsterdam Univ Med Ctr, Dept Eth Law & Humanities, Locat VUmc, De Boelelaan 1117, NL-1081 HZ Amsterdam, Netherlands

来源：

JAMA INTERNAL MEDICINE | 2022年 / 182卷 / 07期

关键词：

D O I：

10.1001/jamainternmed.2022.1551

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This cross-sectional study evaluates the existence and timing of trial registration for randomized clinical trials (RCTs) published from 2002 to 2017 as well as substantive changes to the primary outcomes entered into registry information after those studies started.

引用

页码：779 / 782

页数：4

共 50 条

[1] Clinical Trial Registration and Publication of Randomized Controlled Trials
Lockshin, Michael D.
Katz, Patricia P.
Yelin, Edward H.
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 303 (06): : 517 - 518
[2] Trends in trial registration for randomized clinical trials in eyes and vision
Lindsley, Kristina
Fusco, Nicole
Scholten, Rob
Hooft, Lotty
[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2020, 61 (07)
[3] Clinical Trial Registration and Publication of Randomized Controlled Trials Reply
Mathieu, Sylvain
Boutron, Isabelle
Ravaud, Philippe
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 303 (06): : 518 - 518
[4] Discrepancies in endpoints between clinical trial protocols and clinical trial registration in randomized trials in oncology
Victoria J. Serpas
Kanwal P. Raghav
Daniel M. Halperin
James Yao
Michael J. Overman
[J]. BMC Medical Research Methodology, 18
[5] Discrepancies in endpoints between clinical trial protocols and clinical trial registration in randomized trials in oncology
Serpas, Victoria J.
Raghav, Kanwal P.
Halperin, Daniel M.
Yao, James
Overman, Michael J.
[J]. BMC MEDICAL RESEARCH METHODOLOGY, 2018, 18
[6] Selective registration of non-primary endpoints in randomized clinical trials in oncology: a comparison of endpoint reporting between clinical trial protocols and US national clinical trial registration
Serpas, V.
Halperin, D.
Raghav, K.
Overman, M. J.
[J]. ANNALS OF ONCOLOGY, 2016, 27
[7] Registration of randomized clinical trials - a challenge
Ostervig, R. M.
Sonne, A.
Rasmussen, L. S.
[J]. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2015, 59 (08) : 986 - 989
[8] Immunotherapy: clinical trials - optimal trial and clinical outcomes
Bousquet, Philippe Jean
Demoly, Pascal
Passalacqua, Giovanni
Canonica, G. Walter
Bousquet, Jean
[J]. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 7 (06) : 561 - 566
[9] Patterns of Scientific and Clinical Impact in Cancer Randomized Clinical Trials
Nghiem, Van T.
Vaidya, Riha
Unger, Joseph M.
[J]. JAMA NETWORK OPEN, 2022, 5 (06) : E2219657
[10] Clinical trial registration in fertility trials - a case for improvement?
Farquhar, Cynthia M.
Showell, Marian G.
Showell, Emily A. E.
Beetham, Penny
Baak, Nora
Mourad, Selma
Jordan, Vanessa M. B.
[J]. HUMAN REPRODUCTION, 2017, 32 (09) : 1827 - 1834

← 1 2 3 4 5 →