Concurrent Treatment of Steroid-Related Mood and Psychotic Symptoms With Risperidone

被引：28
|
作者：
Ularntinon, Sirirat [1 ]
Tzuang, Dan [1 ]
Dahl, Gary [2 ,3 ]
Shaw, Richard J. [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Palo Alto, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Pediat, Palo Alto, CA 94305 USA
[3] Lucile Packard Childrens Hosp, Palo Alto, CA USA
来源：
PEDIATRICS | 2010年 / 125卷 / 05期
关键词：
corticosteroid; pediatrics; risperidone; psychosis; BLOOD-BRAIN-BARRIER; CHILDREN; CORTICOSTEROIDS; CANCER; DISORDERS; BEHAVIOR; MEMORY;
D O I：
10.1542/peds.2009-1815
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Corticosteroid treatment is an important therapeutic modality for many pediatric medical conditions including acute lymphoblastic leukemia. However, steroid-induced behavioral and mood abnormalities are common and potentially disabling adverse effects that have been widely reported in the pediatric literature. From this case series, we report the efficacy of risperidone in 3 children with acute lymphoblastic leukemia who developed steroid-related mood and psychotic symptoms during treatment with prednisone and dexamethasone. Risperidone is an effective short-term pharmacologic agent for controlling steroid-related psychiatric adverse effects when cessation or dose reduction of steroid therapy is not an option. Pediatrics 2010; 125: e1241-e1245
引用
收藏
页码：E1241 / E1245
页数：5
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