One-step synthesis of hypoxanthine from glycinamide and diformylurea

被引：13

作者：

Lagoja, IM ^{[1
]}

Herdewijn, P ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, Med Chem Lab, B-3000 Louvain, Belgium

来源：

CHEMISTRY & BIODIVERSITY | 2004年 / 1卷 / 01期

关键词：

D O I：

10.1002/cbdv.200490001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Because of their easy availability and their relative chemical stability, urea, formic acid, and glycine might have played a role in the assembly process of nucleobases. In this paper, a short reaction path is described to prepare hypoxanthine starting from the above mentioned precursors. The formation of hypoxanthine has been verified by high-resolution mass spectrometry with the N-15-labelled urea as starting material, and HPLC analysis. The yield of this condensation reaction has been determined spectrophotometrically.

引用

页码：106 / 111

页数：6

共 50 条

[1] A one-step synthesis of pseudoephedrine glycinamide, a versatile precursor for the synthesis of a-amino acids
Myers, A. G.
Yoon, T.
Gleason, J. L.
Terra Nova, 785
[2] A ONE-STEP SYNTHESIS OF PSEUDOEPHEDRINE GLYCINAMIDE, A VERSATILE PRECURSOR FOR THE SYNTHESIS OF ALPHA-AMINO-ACIDS
MYERS, AG
YOON, TY
GLEASON, JL
TETRAHEDRON LETTERS, 1995, 36 (26) : 4555 - 4558
[3] STUDIES IN PURINE CHEMISTRY .6. A CONVENIENT ONE-STEP SYNTHESIS OF HYPOXANTHINE
TAYLOR, EC
CHENG, CC
TETRAHEDRON LETTERS, 1959, (12) : 9 - 11
[4] One-step synthesis of sulfonamides from tosylhydrazones
Tsai, Andy
Curto, John
Schmitt, Anne-Marie Dechert
Ingle, Gajendra
Mascitti, Vincent
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
[5] ONE-STEP SYNTHESIS OF DINITROPOLYMETHYLBIPHENYLS FROM POLYMETHYLBENZENES
PUSKAS, I
FIELDS, EK
BANAS, EM
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 1970, 15 (03): : 458 - &
[6] A ONE-STEP SYNTHESIS OF FULVENE
KENT, JE
JONES, AJ
AUSTRALIAN JOURNAL OF CHEMISTRY, 1970, 23 (05) : 1059 - +
[7] One-step synthesis of laurencione
Aelterman, W
DeKimpe, N
Kalinin, V
JOURNAL OF NATURAL PRODUCTS, 1997, 60 (04): : 385 - 386
[8] ONE-STEP SYNTHESIS OF PRECOCENES
TIABI, M
ZAMARLIK, H
TETRAHEDRON LETTERS, 1991, 32 (49) : 7251 - 7252
[9] ONE-STEP SYNTHESIS OF HALFORDINOL
ONAKA, T
TETRAHEDRON LETTERS, 1971, (46) : 4393 - &
[10] A ONE-STEP SYNTHESIS OF BROPARESTROL
ALHASSAN, MI
SYNTHESIS-STUTTGART, 1987, (09): : 815 - 816

← 1 2 3 4 5 →