Associations of MTHFR C677T and MTRR A66G Gene Polymorphisms with Metabolic Syndrome: A Case-Control Study in Northern China
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作者:
Yang, Boyi
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China Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R China
Yang, Boyi
[1
]
Fan, Shujun
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China Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R China
Fan, Shujun
[1
]
Zhi, Xueyuan
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China Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R China
Zhi, Xueyuan
[1
]
Wang, Da
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China Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R China
Wang, Da
[1
]
Li, Yongfang
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China Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R China
Li, Yongfang
[1
]
Wang, Yinuo
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Shanghai Inst Targeted Therapy & Mol Med, Div Mol Prevent Med, Shanghai 200433, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R China
Wang, Yinuo
[2
]
Wang, Yanxun
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Shanghai Inst Targeted Therapy & Mol Med, Div Mol Prevent Med, Shanghai 200433, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R China
Wang, Yanxun
[2
]
Wei, Jian
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Tianjin Dagang Oil Field Gen Hosp, Brain Dis Ctr, Tianjin 300280, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R China
Wei, Jian
[3
]
Zheng, Quanmei
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China Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R China
Zheng, Quanmei
[1
]
Sun, Guifan
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China Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R China
Sun, Guifan
[1
]
机构:
[1] China Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R China
[2] Shanghai Inst Targeted Therapy & Mol Med, Div Mol Prevent Med, Shanghai 200433, Peoples R China
[3] Tianjin Dagang Oil Field Gen Hosp, Brain Dis Ctr, Tianjin 300280, Peoples R China
Prior evidence indicates that homocysteine plays a role in the development of metabolic syndrome (MetS). Methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms are common genetic determinants of homocysteine levels. To investigate the associations of the MTHFR C677T and MTRR A66G polymorphisms with MetS, 692 Chinese Han subjects with MetS and 878 controls were recruited. The component traits of MetS and the MTHFR C677T and MTRR A66G genotypes were determined. A significant association was observed between the MTHFR 677T allele and increased risk of MetS, high fasting blood glucose, high waist circumference, and increasing number of MetS components. The MTRR A66G polymorphism was associated with an increased risk of MetS when combined with the MTHFR 677TT genotype, although there was no association found between MetS and MTRR A66G alone. Furthermore, the MTRR 66GG genotype was associated with high fasting blood glucose and triglycerides. Our data suggest that the MTHFR 677T allele may contribute to an increased risk of MetS in the northern Chinese Han population. The MTRR A66G polymorphism is not associated with MetS. However, it may exacerbate the effect of the MTHFR C677T variant alone. Further large prospective population-based studies are required to confirm our findings.
机构:
Guangzhou Med Coll, Afficiated Hosp 2, Inst Neurosci, Guangzhou, Peoples R ChinaGuangzhou Med Coll, Afficiated Hosp 2, Inst Neurosci, Guangzhou, Peoples R China
Xu, E
Deng, B
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Guangzhou Med Coll, Afficiated Hosp 2, Inst Neurosci, Guangzhou, Peoples R ChinaGuangzhou Med Coll, Afficiated Hosp 2, Inst Neurosci, Guangzhou, Peoples R China
Deng, B
Liang, R
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Guangzhou Med Coll, Afficiated Hosp 2, Inst Neurosci, Guangzhou, Peoples R ChinaGuangzhou Med Coll, Afficiated Hosp 2, Inst Neurosci, Guangzhou, Peoples R China
Liang, R
Liu, Z
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Guangzhou Med Coll, Afficiated Hosp 2, Inst Neurosci, Guangzhou, Peoples R ChinaGuangzhou Med Coll, Afficiated Hosp 2, Inst Neurosci, Guangzhou, Peoples R China
Liu, Z
Lu, X
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Guangzhou Med Coll, Afficiated Hosp 2, Inst Neurosci, Guangzhou, Peoples R ChinaGuangzhou Med Coll, Afficiated Hosp 2, Inst Neurosci, Guangzhou, Peoples R China
机构:
Univ Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Univ El Manar II, Ctr Matern & Neonatol La Rabta, Serv Embryofoetopathol, UR 06 SP14 Troubles Dev Embryofoetal & Placentair, Tunis, Tunisia
Univ El Manar II, Fac Med Tunis, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Nasri, Kaouther
Midani, Fatma
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Univ El Manar II, Fac Med Tunis, Tunis, Tunisia
Univ El Manar II, Hop Rabta, Dept Biochim, R 05 08 08, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Midani, Fatma
Kallel, Amani
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Univ El Manar II, Fac Med Tunis, Tunis, Tunisia
Univ El Manar II, Hop Rabta, Dept Biochim, R 05 08 08, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Kallel, Amani
Ben Jemaa, Nadia
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Univ El Manar II, Ctr Matern & Neonatol La Rabta, Serv Embryofoetopathol, UR 06 SP14 Troubles Dev Embryofoetal & Placentair, Tunis, Tunisia
Univ El Manar II, Fac Med Tunis, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Ben Jemaa, Nadia
Aloui, Mariem
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Univ Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Univ El Manar II, Ctr Matern & Neonatol La Rabta, Serv Embryofoetopathol, UR 06 SP14 Troubles Dev Embryofoetal & Placentair, Tunis, Tunisia
Univ El Manar II, Fac Med Tunis, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
机构:
Univ El Manar II, Fac Med Tunis, Tunis, Tunisia
Univ El Manar II, Hop Rabta, Dept Biochim, R 05 08 08, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Lassoued, Mehdi
Ben Halima, Meriam
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Univ El Manar II, Fac Med Tunis, Tunis, Tunisia
Univ El Manar II, Hop Rabta, Dept Biochim, R 05 08 08, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Ben Halima, Meriam
Ben Wafi, Safa
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Univ El Manar II, Fac Med Tunis, Tunis, Tunisia
Univ El Manar II, Hop Rabta, Dept Biochim, R 05 08 08, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Ben Wafi, Safa
Soussi, Mariem
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Univ El Manar II, Fac Med Tunis, Tunis, Tunisia
Univ El Manar II, Hop Rabta, Dept Biochim, R 05 08 08, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Soussi, Mariem
Mahjoubi, Imen
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Univ El Manar II, Fac Med Tunis, Tunis, Tunisia
Univ El Manar II, Hop Rabta, Dept Biochim, R 05 08 08, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Mahjoubi, Imen
Baara, Abir
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Univ El Manar II, Fac Med Tunis, Tunis, Tunisia
Univ El Manar II, Hop Rabta, Dept Biochim, R 05 08 08, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Baara, Abir
Ben Fradj, Mohamed Kacem
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Univ El Manar II, Fac Med Tunis, Tunis, Tunisia
Univ El Manar II, Hop Rabta, Dept Biochim, R 05 08 08, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Ben Fradj, Mohamed Kacem
Omar, Souhail
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Inst Natl Mongi Ben Hmida Neurol, Lab Biol Clin, Rue Jebbari La Rabta, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Omar, Souhail
Feki, Moncef
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Univ El Manar II, Fac Med Tunis, Tunis, Tunisia
Univ El Manar II, Hop Rabta, Dept Biochim, R 05 08 08, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Feki, Moncef
Jemaa, Riadh
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Univ El Manar II, Fac Med Tunis, Tunis, Tunisia
Univ El Manar II, Hop Rabta, Dept Biochim, R 05 08 08, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Jemaa, Riadh
Gaigi, Soumeya Siala
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Univ El Manar II, Ctr Matern & Neonatol La Rabta, Serv Embryofoetopathol, UR 06 SP14 Troubles Dev Embryofoetal & Placentair, Tunis, Tunisia
Univ El Manar II, Fac Med Tunis, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
Gaigi, Soumeya Siala
Marrakchi, Raja
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Univ El Manar II, Fac Sci Tunis, Lab Genet Immunol & Pathol Humaine, Tunis, TunisiaUniv Carthage, Fac Sci Bizerte, Jarzouna 7021, Bizerte, Tunisia
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China Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R ChinaChina Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R China
Yang, Boyi
Liu, Yuyan
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China Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R ChinaChina Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R China
Liu, Yuyan
Li, Yongfang
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China Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R ChinaChina Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R China
Li, Yongfang
Fan, Shujun
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China Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R ChinaChina Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R China
Fan, Shujun
Zhi, Xueyuan
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China Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R ChinaChina Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R China
Zhi, Xueyuan
Lu, Xiangxiang
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China Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R ChinaChina Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R China
Lu, Xiangxiang
Wang, Da
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China Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R ChinaChina Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R China
Wang, Da
Zheng, Quanmei
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China Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R ChinaChina Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R China
Zheng, Quanmei
Wang, Yinuo
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Shanghai Inst Targeted Therapy & Mol Med, Shanghai, Peoples R ChinaChina Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R China
Wang, Yinuo
Wang, Yanxun
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Shanghai Inst Targeted Therapy & Mol Med, Shanghai, Peoples R ChinaChina Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R China
Wang, Yanxun
Sun, Guifan
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China Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R ChinaChina Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Shenyang, Peoples R China
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China Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R China
Fan, Shu-Jun
Yang, Bo-Yi
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China Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R China
Yang, Bo-Yi
Zhi, Xue-Yuan
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China Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R China
Zhi, Xue-Yuan
He, Miao
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China Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R China
He, Miao
Wang, Da
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China Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R China
Wang, Da
Wang, Yan-Xun
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Shanghai Inst Targeted Therapy & Mol Med, Div Mol Prevent Med, Shanghai 200433, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R China
Wang, Yan-Xun
Wang, Yi-Nuo
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Shanghai Inst Targeted Therapy & Mol Med, Div Mol Prevent Med, Shanghai 200433, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R China
Wang, Yi-Nuo
Wei, Jian
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Tianjin Dagang Oil Field Gen Hosp, Brain Dis Ctr, Tianjin 300280, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R China
Wei, Jian
Zheng, Quan-Mei
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China Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R China
Zheng, Quan-Mei
Sun, Gui-Fan
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China Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Res Ctr Environm & Noncommunicable Dis, Shenyang 110013, Peoples R China