Associations of MTHFR C677T and MTRR A66G Gene Polymorphisms with Metabolic Syndrome: A Case-Control Study in Northern China

被引:34
|
作者
Yang, Boyi [1 ]
Fan, Shujun [1 ]
Zhi, Xueyuan [1 ]
Wang, Da [1 ]
Li, Yongfang [1 ]
Wang, Yinuo [2 ]
Wang, Yanxun [2 ]
Wei, Jian [3 ]
Zheng, Quanmei [1 ]
Sun, Guifan [1 ]
机构
[1] China Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Shenyang 110013, Peoples R China
[2] Shanghai Inst Targeted Therapy & Mol Med, Div Mol Prevent Med, Shanghai 200433, Peoples R China
[3] Tianjin Dagang Oil Field Gen Hosp, Brain Dis Ctr, Tianjin 300280, Peoples R China
来源
关键词
MTHFR; MTRR; polymorphism; metabolic syndrome; China; METHIONINE SYNTHASE REDUCTASE; INTERNATIONAL-DIABETES-FEDERATION; PLASMA HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE; INSULIN-RESISTANCE; HYPERHOMOCYSTEINEMIA; DNA; PREVALENCE; RISK; POPULATION;
D O I
10.3390/ijms151221687
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Prior evidence indicates that homocysteine plays a role in the development of metabolic syndrome (MetS). Methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms are common genetic determinants of homocysteine levels. To investigate the associations of the MTHFR C677T and MTRR A66G polymorphisms with MetS, 692 Chinese Han subjects with MetS and 878 controls were recruited. The component traits of MetS and the MTHFR C677T and MTRR A66G genotypes were determined. A significant association was observed between the MTHFR 677T allele and increased risk of MetS, high fasting blood glucose, high waist circumference, and increasing number of MetS components. The MTRR A66G polymorphism was associated with an increased risk of MetS when combined with the MTHFR 677TT genotype, although there was no association found between MetS and MTRR A66G alone. Furthermore, the MTRR 66GG genotype was associated with high fasting blood glucose and triglycerides. Our data suggest that the MTHFR 677T allele may contribute to an increased risk of MetS in the northern Chinese Han population. The MTRR A66G polymorphism is not associated with MetS. However, it may exacerbate the effect of the MTHFR C677T variant alone. Further large prospective population-based studies are required to confirm our findings.
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收藏
页码:21687 / 21702
页数:16
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